VIOLIN: Vaccine Investigation and Online Information Network

Fnz
Gene Name	Fnz
Sequence Strain (Species/Organism)	Streptococcus equi subsp. zooepidemicus
VO ID	VO_0011214
NCBI Gene ID	7695217
NCBI Protein GI	754170878
Locus Tag	SZO_RS08670
Genbank Accession	FM204884
Protein Accession	WP_041790586
Taxonomy ID	40041
Gene Starting Position	1860617
Gene Ending Position	1862326
Gene Strand (Orientation)	+
Protein Name	thioester-forming surface-anchored protein
Protein pI	4.75
Protein Weight	58938.07
Protein Length	569
Protein Note	Ortholog of S. equi 4047 (FM204883) SEQ0375
DNA Sequence	>NC_012470.1:1860617-1862326 Streptococcus equi subsp. zooepidemicus H70, complete genome TATGGAGAGAAGAGAGTTGAAAACAAAATCATTTAGAAAGGTACTGACGACGTCAGCTACCTGTATTGTG CTGGCAACAAGCTTTGCCGGAGGAACCCTACGCGTCTGGGCAGAGCAGCTTTATTATGGGTGGGATGATG GAACGAGACATGATTCACCCTCCTTTTTATATGTAACGCCTACTACTGAAAGTCAAAGAAGCCCCAAAAC TATTGTATACTGTTTTAATCGAAACAATTATTGGCCGGATAATTGGGAAACCCATGTCTTAAAACCAGAT AATCTACCTACTTATAATAAATTAACAGGAACTGCGAAGTTATTTCAAAATAAAGCTACCAAACCAAGAT CGGTAGCAGATATCGAGAAGTCCTTAGTTTCTGTCCTAAGTAAAGGGTATCCAACAAGTAATCTCTCTCA ATTTGGCATCAGTAATGAGTCAGCTAGAATAGTGACACAATTAGCCATTTGGTATTTTAGTGATAGTGTG AACGATCCTGAAAGCGTACTTAGACAAAGATTAGGGGGCAATGAATCTAAAGCATTAAAATACCTTATTG AGGTTGGTGAAAAACCACAATTGAGCGAAGCTGAGCAAAAGCAAACGTTAGATATATACGTTTACAACTC AGGAGGTTATCGTAGAACAGGTTACCAAAATCTTCTCGGCTCTACCTTAATTCCTAAAACACCAGAAAAG CCTTCTTCTGAATCTGTAACTCAGAGTAACCTTATTCTACTTGAACAGGAGAATCATTCTGGTACTATTT CAGGTGGTTCAGGAAATACTGAAACTGAGGAGAATACTCCTCATCTAATGGGGATAGGTGGCGGTCTAGC TGGTGAATCAGGAGAAAACACACCTAAACCAGGGGAAACTGGTGGGCACTCCCCTATAGTTGAAGAAAAC TACGGTAGTACTGAAGAATTTCATGGGAATTCAGAAATTATTAGTGAAACCGAAGATACTAATCCTGGTA TCATTTTAGGTGGCTCAGGAAATGTCGAAACACATGAAGATACTAGGAATCCTCATCTGATGGGGCTTGG CGGTGGTCTAGCTGGCGAATCAGGAGAAACGACACCTAAACCAGGACAGACTGGTGGTCATGGACCAATC ATCGAGACAACAGAGGACACACAAAAAGGCATGTCTGGGCAATCTGGCGGCACTATCGAGTCAGAAAACA CCAAAAAGCCTGAGGTCATGATTGGTGGGCAGGGACAAACCATCGAAACAACAGAGGACACACAAAAAGG CATGTCTGGGCAATCTGGCGGTACTATCGAGTCAGAAGACACTAAAAAACCTGAGGTCATGATTGGCGGT CAGGGACAAATCATCGACTTCTCTGAAAACACGCAATCAGGTATGTCTGGACAGTCTGGAGACACTACGG TCATTGAGGATACCAAGAAGTCTGAGATAATCATTGGTGGGCAAGGACAAATCATCGACTTCTCTGAGGA TACTCAGCCGGGTATGTCTGGGCAATCTGGAGGCACCACAATTGTCGAAGACACCAAGAAGCCGACACCT AAGCCTAAACCTGCACCTGCGCCAATTGTTAATGACGAAAAACCTAACAAAGGCACTCAGCTCCCACAGA CAAATGATATGAAGCAACTCACCCTAAGCATCATCGGTGCAATGTCAATGCTGCTTGTCCTATGTCTGTC TCTATTCAAGCGACCATCTAAAAAAGACTA
Protein Sequence	>WP_041790586.1 thioester-forming surface-anchored protein [Streptococcus equi] MERRELKTKSFRKVLTTSATCIVLATSFAGGTLRVWAEQLYYGWDDGTRHDSPSFLYVTPTTESQRSPKT IVYCFNRNNYWPDNWETHVLKPDNLPTYNKLTGTAKLFQNKATKPRSVADIEKSLVSVLSKGYPTSNLSQ FGISNESARIVTQLAIWYFSDSVNDPESVLRQRLGGNESKALKYLIEVGEKPQLSEAEQKQTLDIYVYNS GGYRRTGYQNLLGSTLIPKTPEKPSSESVTQSNLILLEQENHSGTISGGSGNTETEENTPHLMGIGGGLA GESGENTPKPGETGGHSPIVEENYGSTEEFHGNSEIISETEDTNPGIILGGSGNVETHEDTRNPHLMGLG GGLAGESGETTPKPGQTGGHGPIIETTEDTQKGMSGQSGGTIESENTKKPEVMIGGQGQTIETTEDTQKG MSGQSGGTIESEDTKKPEVMIGGQGQIIDFSENTQSGMSGQSGDTTVIEDTKKSEIIIGGQGQIIDFSED TQPGMSGQSGGTTIVEDTKKPTPKPKPAPAPIVNDEKPNKGTQLPQTNDMKQLTLSIIGAMSMLLVLCLS LFKRPSKKD
Molecule Role	Protective antigen
Molecule Role Annotation	Parts of the three recombinant proteins (FNZ (cell surface-bound fibronectin binding protein), SFS (secreted fibronectin binding protein), and EAG (alpha2-macroglobulin, albumin, and immunoglobulin G [IgG] binding protein)) were used to immunize mice, either subcutaneously or intranasally, prior to nasal challenge with S. equi subsp. equi. The adjuvant used was EtxB, a recombinant form of the B subunit of Escherichia coli heat-labile enterotoxin. It was shown that nasal colonization of S. equi subsp. equi and weight loss due to infection were significantly reduced after vaccination compared with a mock-vaccinated control group. This effect was more pronounced after intranasal vaccination than after subcutaneous vaccination; nearly complete eradication of nasal colonization was obtained after intranasal vaccination (P < 0.001) (Flock et al., 2004).
Related Vaccines(s)	S. equi Subunit EAG, FNZ and SFS Protein Vaccine
References

Fnz