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binding protein Eag
Gene Name	binding protein Eag
Sequence Strain (Species/Organism)	Streptococcus equi subsp. equi 4047
VO ID	VO_0011211
NCBI Gene ID	7696154
NCBI Protein GI	225870123
Locus Tag	SEQ_0721
Genbank Accession	FM204883
Protein Accession	YP_002746070
Other Database IDs	CDD:144825
Taxonomy ID	553482
Gene Starting Position	711797
Gene Ending Position	713086
Gene Strand (Orientation)	?
Protein Name	Ig, alpha2-macroglobulin and albumin binding protein Eag
Protein pI	4.57
Protein Weight	41524.96
Protein Length	429
Protein Note	B domain; pfam01378
DNA Sequence	>NC_012471.1:711797-713086 Streptococcus equi subsp. equi 4047, complete genome AATGGAAAAAAACAAAAAGGTATCCTACTTTTTACGTCAATCAGCTGTTGGTTTAGCTTCAGTGTCGGCA GCCTTTCTGGTTGGAACGACTTCAGTGGGTGCTTTAGACGCAGCAACAGTGTTAGAGCCTACAACAGCCT TCATTAGAGAAGCTGTTAGGGAAATCAATCAGCTGAGTGATGACTACGCTGACAATCAAGAGCTTCAGGC TGTTCTTGCTAATGCTGGAGTTGAGGCACTTGCTGCAGATACTGTTGATCAGGCTAAAGCAGCTCTTGAC AAAGCAAAGGCAGCTGTTGCTGGTGTTCAGCTTGATGAAGCAAGACGTGAGGCTTACAGAACAATCAATG CCTTAAGTGATCAGCACAAAAGCGATCAAAAGGTTCAGCTAGCTCTAGTTGCTGCAGCAGCTAAGGTGGC AGATGCTGCTTCAGTTGATCAAGTGAATGCAGCCATTAATGATGCTCATACAGCTATTGCGGACATTACA GGAGCAGCCTTGTTGGAGGCTAAAGAAGCTGCTATCAATGAACTAAAGCAGTATGGCATTAGTGATTACT ATGTGACCTTAATCAACAAAGCCAAAACTGTTGAAGGTGTCAATGCGCTTAAGGCAGAGATTTTATCAGC TCTACCGAGTTCTGAGGTCATTGACGCAGCAGAACTAACACCAGCCTTGACTAGCTATAAGCTTGTCATC AAGGGAGCAACTTTTTCAGGTGAAACAGCTACTAAGGCAGTAGACGCAGCTGTAGCTGAGCAGACCTTCA GAGACTATGCTAATAAAAATGGTGTAGACGGCGTTTGGGCTTATGATGCTGCCACAAAGACATTTACAGT CACTGAACAGCCTGTAGCTGAGACTATTGAGGCGGCAGAATTAACACCAGCTTTGACCACCTATAGGCTT GTTATTAAGGGGGTTACCTTCTCAGGTGAAACAGCTACCAAGGCAGTAGACGCAGCCACAGCCGAGCAGA CCTTCAGGCAATATGCCAATGACAATGGCGTTACTGGTGAATGGGCTTATGACGCTGCTACAAAGACATT TACAGTCACTGAGGCTTTAGAGGAGAGTCCAGCTGATCCAGAAAAGCCATCAGCTTCTCTTCCGTTGACA CCGCTTACACCAGCAACTAAGACAGCACCAGCTAAGCAAAAAGATAAGCAAAAGGCTAAGACTCTTCCAA CGACTGGTGAGAAGGCTAATCCATTCTTTACAGCAGCGGCTCTTGCCATTATGGCGAGTGCAGGTGCTTT AGCAGTGACTTCAAAGCGTCAGCAGGACTA
Protein Sequence	>YP_002746070.1 Ig, alpha2-macroglobulin and albumin binding protein Eag [Streptococcus equi subsp. equi 4047] MEKNKKVSYFLRQSAVGLASVSAAFLVGTTSVGALDAATVLEPTTAFIREAVREINQLSDDYADNQELQA VLANAGVEALAADTVDQAKAALDKAKAAVAGVQLDEARREAYRTINALSDQHKSDQKVQLALVAAAAKVA DAASVDQVNAAINDAHTAIADITGAALLEAKEAAINELKQYGISDYYVTLINKAKTVEGVNALKAEILSA LPSSEVIDAAELTPALTSYKLVIKGATFSGETATKAVDAAVAEQTFRDYANKNGVDGVWAYDAATKTFTV TEQPVAETIEAAELTPALTTYRLVIKGVTFSGETATKAVDAATAEQTFRQYANDNGVTGEWAYDAATKTF TVTEALEESPADPEKPSASLPLTPLTPATKTAPAKQKDKQKAKTLPTTGEKANPFFTAAALAIMASAGAL AVTSKRQQD
Molecule Role	Protective antigen
Molecule Role Annotation	Vaccination of mice with EAG (α2-macroglobulin, albumin, and immunoglobulin G [IgG] binding protein) as a single antigen with EtxB (as an adjuvant) induced protection in mice against bacterial challenge, but was less protective than at affording protection than immunization with FNZ, SFS, EAG, and EtxB (Flock et al., 2004). The antigens used were EAG (alpha2-macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The vaccinated horses showed significantly reduced bacterial growth (p=0.02).(Waller et al., 2007)
Related Vaccines(s)	S. equi Subunit EAG, FNZ and SFS Protein Vaccine
References

binding protein Eag