VIOLIN: Vaccine Investigation and Online Information Network

PiaA
Gene Name	PiaA
Sequence Strain (Species/Organism)	Streptococcus pneumoniae D39
VO ID	VO_0011207
NCBI Gene ID	4442863
NCBI Protein GI	WP_000731179
Locus Tag	SPD_0226
Genbank Accession	CP000410
Protein Accession	YP_815744
Other Database IDs	CDD:328725
Taxonomy ID	1313
Gene Starting Position	216000
Gene Ending Position	216368
Gene Strand (Orientation)	-
Protein Name	extracellular solute-binding protein
Protein pI	4.84
Protein Weight	35132.62
Protein Length	424
Protein Note	Type 2 periplasmic binding fold superfamily; cl21456
DNA Sequence	>NC_008533.1:216000-216368 Streptococcus pneumoniae D39, complete genome TTTACTGTTTAGATTGGATATCTGTAAAGACTTCGTTGTATTTCTTAACGATATCTGATTTATTCTTGAT GACATAATCATAATCTTCAGTGAGTGTTTTGATTTTGTCAATTGGTTTCATGTTTTCGCTTGTTTTAGCA TTTTTACGAACAGGACGGTTAGTAGTGGTTGTACCAAGTGTATCTTGTACTTCTTGAGAGATAATAAAAT CGATAAATTTCTTGGCATTTTCCATATTTTTAGATTTTTTAACGATAGCAGCACTAGCAGGTAGGAAGAC GGTTCCTTCTTTTGGATAGACTACTTTAATGTTAGCTCCGTCATTTAAGAGTTTAACTGCTGAATCTTCA TAAGAGAGACCAACAGTCA
Protein Sequence	>WP_000731179.1 extracellular solute-binding protein [Streptococcus pneumoniae] MKKKWMYYAACSSNESADDSSSDKGDGGSLVVYSPNSEGLIGATIPAFEEKYGIKVELIQAGTGELFKKL ESEKEVPVADVIFGGSYTQYTTHGELFENYTSKENDNVIKEYQNTTGYSTPYTLDGSVLIVNPDLTKGMN IEGYNDLFKPELKGKIATADPANSSSAFAQLTNMLQAQGGYKDDKAWSYVKDLFTLIDGKIGSSSSSVYK VVADGEMAVGLSYEDPAVKLLNDGANIKVVYPKEGTVFLPASAAIVKKSKNMENAKKFIDFIISQEVQDT LGTTTTNRPVRKNAKTSENMKPIDKIKTLTEDYDYVIKNKSDIVKKYNEVFTDIQSKQ
Molecule Role	Protective antigen
Molecule Role Annotation	Mice immunized with recombinant PiaA were protected against systemic challenge to a degree similar to those immunized with an existing protein vaccine candidate, PdB (a genetically modified pneumolysin toxoid). Immunization with a combination of both PiuA and PiaA resulted in additive protection and was highly protective against systemic infection with S. pneumoniae (Brown et al., 2001).
Related Vaccines(s)	S. pneumoniae PiaA Protein Vaccine
References

PiaA