VIOLIN: Vaccine Investigation and Online Information Network

MIC1
Gene Name	MIC1
Sequence Strain (Species/Organism)	Neospora caninum
VO ID	VO_0011200
NCBI Gene ID	13440244
NCBI Protein GI	17226315
Other Database IDs	CDD:287526 CDD:151915
Taxonomy ID	29176
Gene Strand (Orientation)	?
Protein Name	microneme-associated protein
Protein pI	4.56
Protein Weight	45856.53
Protein Length	528
Protein Note	Sialic-acid binding micronemal adhesive repeat; pfam10564
Protein Sequence	>AAL37729.1 microneme-associated protein [Neospora caninum] MGQSVVFVMLLSVIFTAGAKTYGEASQPSASARSLQGALDTWCQEVFKKLCDDGYSKMCIPANQVVARQG LGRKDQQKLVWRCYDSAAFLAEGDENNVLSCVDDCGVSIPCPGGVDRDNSTHATRHDELSQLIKEGVVRY CSGFQAAANSYCNKRYPGTVARKSKGFGHKEPVKWRCYKPESLLFSVFSECVSNCGTTWSCPGGRLGTAT NLDKKHFTDESGILQALTSVPKACPVGLVCLPRDQNPPACLDDNGNVPEEEGGQPVQPRDTKLPVDDSEP TDESETTPGGGDDQPSPKEDGDTDSPDEGDQSGGSEWYKQIPEIRVIGDSLQAMLHAGQQLMVTYSSPQL HVSVGSCHKLTVNFSDYYLSFDTTSKSGSDEVELDDAAGSGELTIGLGSSGRVTVVFQYATNGGGNRYVA YTVGDSGCKTIEAVLLHGLNPGAKLVRNTIGDNSPGESEL
Molecule Role	Protective antigen
Molecule Role Annotation	Study assessed the potential protectivity of NcMIC1-based vaccination against experimental N. caninum infection in mice. Quantitative real-time PCR revealed that the infection intensity was significantly reduced in the group vaccinated with recNcMIC1 antigen. Serological analysis showed that only recNcMIC1-immunized animals generated detectable antibody levels recognizing native NcMIC1. Thus, of all protocols applied, only recNcMIC1 vaccination appears to be suited to reduce cerebral infection in mice challenged with N. caninum tachyzoites (Alaeddine et al., 2005).
Related Vaccines(s)	N. caninum NcMIC1 Protein Vaccine , RB51--MIC3/GRA2/GRA6/MIC1/SRS2
References

MIC1