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SrtA
Gene Name	SrtA
Sequence Strain (Species/Organism)	Streptococcus pneumoniae D39
VO ID	VO_0011199
NCBI Gene ID	4442999
NCBI Protein GI	116515518
Locus Tag	SPD_1076
Genbank Accession	CP000410
Protein Accession	YP_816547
Taxonomy ID	373153
Gene Starting Position	1102250
Gene Ending Position	1102993
Gene Strand (Orientation)	-
Protein Name	sortase
Protein pI	5.46
Protein Weight	26445.89
Protein Length	247
Protein Note	equivalent gene in S.pneumoniae TIGR4 = SP1218; equivalent gene in S.pneumoniae R6 = spr1098; identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076
DNA Sequence	>NC_008533.1:1102250-1102993 Streptococcus pneumoniae D39, complete genome ATTAATAAAATTGTTTATATGGTTGATTGAAAGCTGTTAGGATTTCATCAGATGTTTGTGAATAATCTTT TGTTTCTTTCAAATCACCTTTGACAATAATACGTTCTGTAGCAGCAAGGTCTTCACAGGTTACTAATGTG ATTTCATTGACCCCATCTCTATCATCAACTTCATCAACACGATCTGGTGTCACACGTTTGACTTCACGTA TTTCATAAGTATAAACTTTATTTTTATCGGTTAGATAAATCTTCATGCCATTTTTAGCATTATCTAAAGG AGAAAATAACATTTTATTAGCATTATCAACACCAAAGATATGGTGACTAGCTAGACTATAATTTCCTTCT CCCATTACTTGCTCGCGTTTCATTGTACCAGCTCCGTAGAAGAGATTAACATTATCAAGTCCTTTAAAAA TCGGCAAATTCATTTCCAATTCAGGAATTGCAATTCCCCCAATAACTGGTAATTTTTGAGCATCCCATTG AGAAGTTAGAACAGCTTCCGAAGAGATAGCTTTGACAGAATCAAAGTCAAAATTGCCTTCTGTATCCTGA TTTTCTTCTAATTTTTCTTTTGATACCTGGCTAACTTGATACTTATTGGTATTCCAGACTATGAAAATAT TTCGAATTTGAGTATTAAAAATCAAAGCCAGTGACAGTAATATCAGAAATCCTGCTAGGATATTTGTCAG CAGATTTTTTCGCTTGTTTTTCTTTTTATTATTTTTTTGAGACA
Protein Sequence	>YP_816547.1 sortase [Streptococcus pneumoniae D39] MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVWNTNKYQVSQVSKEKLEENQDTEGNFD FDSVKAISSEAVLTSQWDAQKLPVIGGIAIPELEMNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLAS HHIFGVDNANKMLFSPLDNAKNGMKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDL AATERIIVKGDLKETKDYSQTSDEILTAFNQPYKQFY
Molecule Role	Protective antigen
Molecule Role Annotation	Intraperitoneal immunization with recombinant SrtA was found to have conferred to mice protection against S. pneumoniae intraperitoneal challenge and the passive transfer of immune serum before intraperitoneal challenge was also protective. Moreover, by using the intranasal challenge model, significant reduction of bacteremia when mice were intraperitoneally immunized with SrtA was observed, while a moderate decrease of lung infection was achieved by intranasal immunization, even though no influence on nasopharynx colonization was seen (Gianfaldoni et al., 2009).
Related Vaccines(s)	S. pneumoniae SrtA Protein Vaccine
References

SrtA