VIOLIN: Vaccine Investigation and Online Information Network

p67
Gene Name	p67
Sequence Strain (Species/Organism)	Theileria parva strain Mugaga
VO ID	VO_0011183
NCBI Protein GI	4106806
Other Database IDs	CDD:253298
Taxonomy ID	5875
Gene Strand (Orientation)	+
Protein Name	p67 surface antigen
Protein pI	4.7
Protein Weight	70967
Protein Length	771
Protein Note	Sporozoite P67 surface antigen; pfam05642
Protein Sequence	>AAD03021.1 p67 surface antigen [Theileria parva] MQITQFLLIIPVFFVSAGDKMPTEEQPFPSRLGPLVTLESAITQPTPVYTMRTVGNVSKAAKVWKSAVSS PDVSTTILTPVSEENITSTLQTQTEEVPAASGSDSSRATNLVQTQSQVQDNVKQQQDTKGNRSDSEEENE DGTLSTDVSPAIPTPVSEEIITPTLQAQTKEEVPPADLSDQVPSNGSDSEEEDEDSSLGTDERGLKKTLP PGKTSTGETTSDQDLKTKQQKNGVSGPAGGSHSSGLKVPGLGVPGEVSPQGGQSLASNTSREGQTQHHQV RDGDGRVIEPKIGLPGPPSAPEPSPGAPGIKVRESGNRAMDIVQFLGRFRPEPRAYEGERTNVAELKKFL FEELESLVNTLIELKLAIANDFVEITDGLRKNTKDHEARLKLLTGVEFTKRKSAANVVKGFSSLYCVLLM NMNVIKEKTKESEVADGIWKLSTIPDKVANELLLAMEKIVVPPKTPELDEAFKEIEFGFKIAYYATKDIL SSIENTVHNLMHAKNYEENFIAQVRNSLRMVPHQMNLTESSFVIKISDMMRRRGTASQDEPAGAGSGVTP GRGSSGTPGAAGTGGGSLRGFDLSEEEVKKILDEIVKDPSDGELGLGDLSDPSGRSSGRQPSLGPSLGIT DGQAGPTIVSPTGPTIAAGGEQPPSAPNGTATGPAGTQPEGGEKKEGLIQKLKKKLLGSGFEVASLMIPM ATIIISIVH
Molecule Role	Protective antigen
Molecule Role Annotation	Immunization with recombinant forms of a sporozoite surface antigen (r-p67), derived from either bacterial or insect cells, induces high levels of sporozoite neutralizing antibodies in cattle.In vivo immunization studies have shown that approximately 30% of immunized cattle are nonreactors to a needle LD70 sporozoite challenge, 40% experience a mild disease reaction from which they recover, and the remaining 30% suffer severe disease and are clinically indistinguishable from controls. Transient parasitosis and mild clinical reactions are also observed in challenge of cattle immunized by infection and treatment and such responses constitute immunity to ECF. Hence, p67 is able to routinely induce immunity at a level of about 70% (Morzaria et al., 2000).
Related Vaccines(s)	T. parva Subunit p67 Protein Vaccine
References

p67