VIOLIN: Vaccine Investigation and Online Information Network

P1
Gene Name	P1
Sequence Strain (Species/Organism)	Neisseria meningitidis MC58
VO ID	VO_0011180
NCBI Gene ID	902192
NCBI Protein GI	15676020
Locus Tag	NMB0088
Genbank Accession	AE002098
Protein Accession	NP_273150
Taxonomy ID	122586
Gene Starting Position	99776
Gene Ending Position	101176
Gene Strand (Orientation)	-
Protein Name	outer membrane protein P1
Protein pI	9.85
Protein Weight	47342.37
Protein Length	466
Protein Note	identified by similarity to EGAD:16317; match to protein family HMM PF03349
DNA Sequence	>NC_003112.2:99776-101176 Neisseria meningitidis MC58 chromosome, complete genome TTTATTTGAATTTGTAGGTGTATTGCAGACCGATGATGTCGGCGTGGTTTTTGAAACGTGCGGAAGACGC GCCTTTGCTGTCCACATCGTTGCCGCTTGCCTTCGCCGTGCGGTAGCTGGTGTCGTTGATGTGGATGTGG GTGTAGGCGGCATCGACGACGTGGTTTTTACCGATATGGTATTTCATACCGGCGGAGAACCAGATGCGGT TGCCGTCGGGTAGGCTGTTCATGCGGTAGTCGGCGTTGCGGACGGGCGATTTGTCAAAAGCGATGCCGGC GCGCAGTTGCAGCGGTTCGCTGATTTGATAAGAACCGCCGAAGCCGACTTTGTAGGTGTTGCGCCAGTTG GGGGTGATGGTGGTGCGGTCGGATTTGCCTTTGACGACGGTTTTTTCTTTTTCAAAAACCAGTTCCGCCT TATCGAAGCGGCTGTGGCGCGTCCAAGTTACGTCGCCGAACAGGTCGGCTTTATCGGACACTTTGTACAT ACCGTGTACGGACAAAGACTCAGGCGTAACGATTTTAACGCGGGCTTTTTCATTCGCCGTGTAGCCGTTT GCTGCAAGCATCGTACTCCACATTGCTTTCGCCGCCGCGCCGTCTGCCGCCCATTCGGCATCGCCTTTGA GCGTGTGCGAGACTTTGGAACGGTAGTTCACGCCCACGCGCGCACGGTCGTTGATGTCCCACATCCACGC CAGTTGGTAGCCGAAGCCCCAATCGCTGCCTTTGACATCGGCGTGTCCGTCGGCCTGAATTTTTGCAGCT TCGGCTACACCGTTAGGTTTGGGCGGTTTTGCCGTCAATATCTCTGCTTTACTCTTAATCCCCCAGTCGG CATATTTGCGCAGTTCGGCGGAAGTATGTTGGGCGATGATGCCTGCGCCGAAGGAATGGCGGTCGTTGAG TTTCCACGCGGCGACAGGTTCGACGGCGATGCTGGTCAGACCGAGTTTGTTGATGTTGTGGCGCAACACG GAATCTTTTTCGTATTCGGTGGCAGAGCCGAAGGGGACGTACACGCCCAAGCCCACGGTCAGATTGTCGT TGACTTTGTATGCGCCGTAGATGTGGGGCGCGACCGTGGTTTTGGTGATTTTGCCGCTTTTCGAACCTTG GACGGGAAGCCCGGTAAAGTCGGTGGCGGAATCCGCCTCATAATGAATGCTGGGCAGCACGATGTTGGCG TTGACGGAAATCTGGCTGCTGTCGAGTTTGGTCAGGCCGGCAGGGTTGTAGAAGATGGTCGATGCGTCGG CGGCTTCTGCGGCGGCGGCATTTGCCGTGCTTTGCGCGTTGACCGACTGTGTGCCGAAGTGGTAGCCGGA TGCGTGGACGGATGCGGCGGCAAAGGCAGTGCCGAGCAGCAGGACGGTTTTTTTCAGTGCGGAAGGGGTC A
Protein Sequence	>NP_273150.1 outer membrane protein P1 [Neisseria meningitidis MC58] MTPSALKKTVLLLGTAFAAASVHASGYHFGTQSVNAQSTANAAAAEAADASTIFYNPAGLTKLDSSQISV NANIVLPSIHYEADSATDFTGLPVQGSKSGKITKTTVAPHIYGAYKVNDNLTVGLGVYVPFGSATEYEKD SVLRHNINKLGLTSIAVEPVAAWKLNDRHSFGAGIIAQHTSAELRKYADWGIKSKAEILTAKPPKPNGVA EAAKIQADGHADVKGSDWGFGYQLAWMWDINDRARVGVNYRSKVSHTLKGDAEWAADGAAAKAMWSTMLA ANGYTANEKARVKIVTPESLSVHGMYKVSDKADLFGDVTWTRHSRFDKAELVFEKEKTVVKGKSDRTTIT PNWRNTYKVGFGGSYQISEPLQLRAGIAFDKSPVRNADYRMNSLPDGNRIWFSAGMKYHIGKNHVVDAAY THIHINDTSYRTAKASGNDVDSKGASSARFKNHADIIGLQYTYKFK
Molecule Role	Protective antigen
Molecule Role Annotation	Seventeen monoclonal antibodies to one of three main cell surface antigens of Neisseria meningitidis group B were tested for protective efficacy in the infant rat using as challenge seven strains of different class 2/3 protein serotypes. Survival of the animals was regularly obtained with antibodies to the P1 protein and to LPS (Saukkonen et al., 1989).
References

P1