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NP from Lake Victoria marburgvirus

Gene Name NP from Lake Victoria marburgvirus
Sequence Strain (Species/Organism) Lake Victoria marburgvirus
VO ID VO_0011163
NCBI Protein GI 332181
Other Database IDs CDD:283221
CDD:274446
Taxonomy ID 11269
Gene Strand (Orientation) ?
Protein Name nucleoprotein
Protein pI 4.71
Protein Weight 73740.44
Protein Length 755
Protein Note Ebola nucleoprotein; pfam05505
Protein Sequence 
>AAA46563.1 nucleoprotein [Marburg marburgvirus]
MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKD
KFNTSPVAKYLRDAGYEFDVIKNADATRFLDVSPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFL
PKLVVGDRASIEKALRQVTVHQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAY
DSIISNSVGQTRFSGLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFAR
VLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEVKLQRRHEHQEIQAIAE
DDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIENNIVEDQGFKQSQNRVSQSFLNDPTPVE
VTVQARPMNRPTALPPPVDDKIEHESTEDSSSSSSFVDLNDPFALLNEDEDTLDDSVMIPGTTSREFQGI
PEPPRQSQDLNNSQGKQEDESTNRIKKQFLRYQELPPVQEDDESEYTTDSQESIDQPGSDNEQGVDLPPP
PLYAQEKRQDPIQHPAANPQDPFGSIGDVNGDILEPIRSPSSPSAPQEDTRMREAYELSPDFTNDEDNQQ
NWPQRVVTKKGRTFLYPNDLLQTNPPESLITALVEEYQNPVSAKELQADWPDMSFDERRHVAMNL
Molecule Role Protective antigen
Molecule Role Annotation Nonhuman primates (cynomolgus macaques) were inoculated with VEE replicons expressing MBGV GP and/or NP and challenged with MGBV. MBGV NP afforded incomplete (partial) protection, sufficient to prevent death but not disease in two of three macaques (Hevey et al., 1998).
Related Vaccines(s) Marburg Virus Nucleoprotein Vaccine , Marburg virus recombinant vector vaccine MBGV GP
References