VIOLIN: Vaccine Investigation and Online Information Network

NH
Gene Name	NH
Sequence Strain (Species/Organism)	Leishmania donovani
VO ID	VO_0011161
NCBI Protein GI	19697561
Other Database IDs	CDD:239117
Taxonomy ID	5661
Gene Strand (Orientation)	?
Protein Name	nucleoside hydrolase
Protein pI	6.51
Protein Weight	30583.64
Protein Length	375
Protein Note	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; cd02651
Protein Sequence	>AAG02281.1 nucleoside hydrolase [Leishmania donovani] MPRKIILDCDPGIDDAVAIFLAHGNPEVELLAITTVVGNQTLEKVTRNARLVADVAGIVGVPVAAGCTKP LVRGVRNASQIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEP RIVDRVKEVVLMGGGYHTGNASPVAEFNVFVDPEAAHIVFNESWNVTMVGLDLTHQALATPAVQKRVKEV GTKPAAFMLQILDFYTKVYEKERNTYATVHDPCAVAYVIDPTVMTTEQVPVDIELNGALTTGMTVADFRY PRPKHCHTQVAVKLDFDKFWCLVIDALKRIGDPQ
Molecule Role	Protective antigen
Molecule Role Annotation	Experimental infection of immunized BALB/c mice demonstrated that the VR1012-NH36 DNA vaccine derived from the nucleoside hydrolase gene (NH) of L. donovani induced an 88% reduction in L. chagasi parasite load and a 65% reduction in L. mexicana lesion size (Aguilar-Be et al., 2005).
Related Vaccines(s)	L. donovani DNA Vaccine encoding NH36 Protein
References