VIOLIN: Vaccine Investigation and Online Information Network

GRP-78
Gene Name	GRP-78
Sequence Strain (Species/Organism)	Leishmania donovani
VO ID	VO_0011152
NCBI Gene ID	13386966
NCBI Protein GI	16797868
Other Database IDs	CDD:240227 CDD:212681
Taxonomy ID	5661
Gene Strand (Orientation)	?
Protein Name	glucose-regulated protein 78
Protein pI	4.92
Protein Weight	63125.03
Protein Length	710
Protein Note	heat shock 70 kDa protein; Provisional
Protein Sequence	>AAL29192.1 glucose-regulated protein 78, partial [Leishmania donovani] GKVEAPCVGVDLGTTYSVAGVWQKGEVHIVTNEMGNRITPSVVAFTDAERLVGDGAKNQLPQNPENTIYA IKRLIGRKYVDPTVQNDKKLLSYHIVADKTGKPLVQVTVKGQQKRFTPEEVSAMVLQKMKEISETFLGEK VKNAVVTVPAYFNDAQRQATKDSGKIAGLNVVRIINEPTAAAIAYGLNKAGEKNILVFDLGGGTFDVSLA DNRRGFFEVVATNGDTHLGGEDFDNNMMKFFVDGLKRKQNVDISNDQKALARLRKACEAAKRQLSSHPEA RVEVDSLVEGYDFSEKITRAKFEELNMALFKNTLVPVQKVLEDAKLKKSDIDEIVLVGGSTRIPKVQQLI KDFFSGKEPNKGINPDEAVAYGAAVQAAVLTGESEVGGKVVLVDVIPLSLGIETVGGVMTKLIERNTQIP TKKSQIFSTYQDNQPSVLIQVFEGERGMTKDNRLLGKFDLSGIPPAPRGVPQIEVAFDVDENSILQVTAS DKSSGKREEITITNDKGRLSEEEIERMVREAAEFEDEDRKVRERVEAKNSLESIAYSLRNQINDKDKLGD KLAADDKKAIEEAVKDALDFVDENPNADREEFEAARTKLQSVTNPIIQKVYQGTAGSGAEEADAMDDL
Molecule Role	Protective antigen
Molecule Role Annotation	BALB/c mice were immunized with a vaccine expressing the 78kDa (GRP-78) antigen of Leishmania donovani. Challenge infection was given intracardially after 2 weeks of second booster. A significant decrease in parasite burden was seen in vaccinees over the infected controls on all post challenge days and was found that maximum protection was provided by 78kDa+rIL-12 vaccine. It was highly immunogenic as depicted by the reduction in parasite load (71-94.8%) (Nagill and Kaur, 2010).
Related Vaccines(s)	L. donovani GRP-78 Protein Vaccine
References

GRP-78