VIOLIN: Vaccine Investigation and Online Information Network

PreM
Gene Name	PreM
Sequence Strain (Species/Organism)	Japanese encephalitis virus
VO ID	VO_0011150
NCBI Protein GI	14600066
Other Database IDs	CDD:279856 CDD:279358
Taxonomy ID	11072
Gene Strand (Orientation)	?
Protein Name	preM protein
Protein pI	8.58
Protein Weight	18091.15
Protein Length	235
Protein Note	Flavivirus polyprotein propeptide; pfam01570
Protein Sequence	>AAK71232.1 preM protein, partial [Japanese encephalitis virus] MKLSNFQGKLLMTINNTDIADVIVIPTSKGENRCWVRAIDVGYMCEDTITYECPKLTMGNDPEDVDCWCD NQEVYVQYGRCTRTRHSKRSRRSVSVQTHGESSLVNKKEAWLDSTKATRYLMKTENWIIRNPGYAFLAAA LGWMLGSNNGQRVVFTILLLLVAPAYS
Molecule Role	Protective antigen
Molecule Role Annotation	A cDNA clone representing the genome of structural proteins of Japanese encephalitis virus (JEV) was inserted into the thymidine kinase gene of vaccinia virus strains LC16mO and WR. Inoculation of rabbits with the infectious recombinant vaccinia virus resulted in rapid production of antiserum specific for the PreM and E glycoproteins of JEV. Mice vaccinated with the recombinant produced JEV-neutralizing antibodies and were resistant to challenge with JEV (Yasuda et al., 1990).
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