VIOLIN: Vaccine Investigation and Online Information Network

NS3
Gene Name	NS3
Sequence Strain (Species/Organism)	Japanese encephalitis virus
VO ID	VO_0011148
NCBI Protein GI	27696332
Other Database IDs	CDD:279317 CDD:214692 CDD:284962 CDD:238005 CDD:304359 CDD:238034
Taxonomy ID	11072
Gene Strand (Orientation)	?
Protein Name	non-structural protein NS3
Protein pI	7.14
Protein Weight	64684.98
Protein Length	699
Protein Note	proteinase and putative helicase
Protein Sequence	>NP_775670.1 non-structural protein NS3 [Japanese encephalitis virus] GGVFWDTPSPKPCSKGDTTTGVYRIMARGILGTYQAGVGVMYENVFHTLWHTTRGAAIMSGEGKLTPYWG SVKEDRIAYGGPWRFDRKWNGTDDVQVIVVEPGKAAVNIQTKPGVFRTPFGEVGAVSLDYPRGTSGSPIL DSNGDIIGLYGNGVELGDGSYVSAIVQGDRQEEPVPEAYTPNMLRKRQMTVLDLHPGSGKTRKILPQIIK DAIQQRLRTAVLAPTRVVAAEMAEALRGLPVRYQTSAVQREHQGNEIVDVMCHATLTHRLMSPNRVPNYN LFVMDEAHFTDPASIAARGYIATKVELGEAAAIFMTATPPGTTDPFPDSNAPIHDLQDEIPDRAWSSGYE WITEYAGKTVWFVASVKMGNEIAMCLQRAGKKVIQLNRKSYDTEYPKCKNGDWDFVITTDISEMGANFGA SRVIDCRKSVKPTILEEGEGRVILGNPSPITSASAAQRRGRVGRNPNQVGDEYHYGGATSEDDSNLAHWT EAKIMLDNIHMPNGLVAQLYGPEREKAFTMDGEYRLRGEEKKNFLELLRTADLPVWLAYKVASNGIQYTD RRWCFDGPRTNAILEDNTEVEIVTRMGERKILKPRWLDARVYADHQALKWFKDFAAGKR
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers constructed plasmid DNAs encoding JE virus proteins. Cytotoxic T lymphocytes (CTLs) were induced by NS3 in a mouse model. Three immunizations with pUJENS3 provided a 50% partial protection from a lethal dose of JE virus (Konishi et al., 2003).
Related Vaccines(s)	Japanese encephalitis virus DNA vaccine pUJENS3
References