VIOLIN: Vaccine Investigation and Online Information Network

HA
Gene Name	HA
Sequence Strain (Species/Organism)	Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))
VO ID	VO_0011139
NCBI Protein GI	206812650
Other Database IDs	CDD:278910
Taxonomy ID	563925
Gene Strand (Orientation)	?
Protein Name	hemagglutinin
Protein pI	7.03
Protein Weight	60115.68
Protein Length	651
Protein Note	Haemagglutinin; pfam00509
Protein Sequence	>ACI22603.1 hemagglutinin [Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))] METVSIITMLLVVTVSNADKICIGYQSTNSTETVDTLTENNVPVTHAKELLHTEHNGMLCATTLGNPLIL DTCTIEGLIYGNPSCDLLLGGREWSYIVERPSAVNGLCYPGNVENLEELRSLFSSASSYQRIQIFPDTIW NVSYSGTSKACSDSFYRSMRWLTQKNNAYPIQDAQYTNNREKNILFMWGINHPPTDTVQTNLYTRTDTTT SVATEEINRTFKPLIGPRPLVNGLQGRIDYYWSVLKPGQTLRIRSNGNLIAPWYGHILSGESHGRILKTD LKRGSCTVQCQTEKGGLNTTLPFQNVSKYAFGNCSKYVGVKSLKLAVGLRSVPSRSSRGLFGAIAGFIEG GWSGLVAGWYGFQHSNDQGVGMAADKDSTQKAIDKITSKVNNIVDKMNKQYEIIDHEFSEVETRLNMINN KIDDQIQDIWAYNAELLVLLENQKTLDEHDANVNNLYNKVKRALGSNAVEDGKGCFELYHKCDDQCMETI RNGTYNRRKYQEESKLERQRIEGVKLESEGTYKILTIYSTVASSLVVAMGFAAFLFWAMSNGSCRCNICI
Molecule Role	Protective antigen
Molecule Role Annotation	Using reverse genetics, we constructed a recombinant NDV expressing an H9 AIV hemagglutinin (HA) from an H9N2 field isolate, A/Chicken/ Shandong/2/2007. When tested, 90% of chickens were protected from clinical disease, mortality, and virus shedding against challenge with homologous H9N2 AIV (Ge et al., 2010).
References