VIOLIN: Vaccine Investigation and Online Information Network

NP
Gene Name	NP
Sequence Strain (Species/Organism)	Influenza A virus (A/chicken/Henan/12/2004(H5N1))
VO ID	VO_0011134
NCBI Protein GI	61698066
Other Database IDs	CDD:278907
Taxonomy ID	319102
Gene Strand (Orientation)	?
Protein Name	nucleocapsid protein
Protein pI	9.73
Protein Weight	54851.512
Protein Length	592
Protein Note	Influenza virus nucleoprotein; pfam00506
Protein Sequence	>AAX53533.1 nucleocapsid protein [Influenza A virus (A/chicken/Henan/12/2004(H5N1))] MASQGTKRSYEQMETGGERQNATEIRASVGRMVSGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSA FDERRNRYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWH SNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGE NGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACV YGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGT RVVPRGQLSTRGVQIASNENMEAMDSNTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPF ERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMNNEGSYFFG DNAEEYDN
Molecule Role	Protective antigen
Molecule Role Annotation	Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with NP plasmid showed 60-80% survival rate with at least three immunizations. The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus (Chen et al., 2009).
Related Vaccines(s)	Influenza virus DNA vaccine encoding NP from Influenza A virus (A/chicken/Henan/12/2004(H5N1))
References

NP