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YscF from Y. pestis CO92
Gene Name	YscF from Y. pestis CO92
Sequence Strain (Species/Organism)	Yersinia pestis CO92
VO ID	VO_0010913
NCBI Gene ID	1172700
NCBI Protein GI	16082743
Locus Tag	YPCD1.55
Genbank Accession	AL117189
Protein Accession	NP_395189
Taxonomy ID	214092
Plasmid No	pCD1
Gene Starting Position	41025
Gene Ending Position	41288
Gene Strand (Orientation)	+
Protein Name	needle complex major subunit
Protein pI	7.54
Protein Weight	9092.63
Protein Length	87
Protein Note	type III secretion apparatus component
DNA Sequence	>NC_003131.1:41025-41288 Yersinia pestis CO92 plasmid pCD1, complete sequence AATGAGTAACTTCTCTGGATTTACGAAAGGAACCGATATCGCAGACTTAGATGCGGTGGCTCAAACGCTC AAGAAGCCAGCAGACGATGCAAACAAAGCGGTTAATGACTCGATAGCAGCATTGAAAGATAAGCCTGACA ACCCGGCGCTACTTGCTGACTTACAACATTCAATTAATAAATGGTCGGTAATTTACAATATAAACTCAAC CATAGTTCGTAGCATGAAAGACTTAATGCAAGGCATCCTACAGAAGTTCCCATA
Protein Sequence	>NP_395189.1 needle complex major subunit (plasmid) [Yersinia pestis CO92] MSNFSGFTKGTDIADLDAVAQTLKKPADDANKAVNDSIAALKDKPDNPALLADLQHSINKWSVIYNINST IVRSMKDLMQGILQKFP
Molecule Role	Protective antigen
Molecule Role Annotation	Ten mice were inoculated subcutaneously, administered booster injections after one month, and challenged with 130 LD(50) of wild type Y. pestis CO92. The vaccinated animals produced high levels of specific antibodies against YscF as determined by Western blot. The data were statistically significant (P = 0.053 by two-tailed Fisher's test), suggesting that the YscF protein can provide a protective immune response against lethal plague challenge during subcutaneous plague infection (Swietnicki et al., 2005).
Related Vaccines(s)	Y. pestis YscF Protein Vaccine , Y. pestis YscF subunit vaccine
References

YscF from Y. pestis CO92