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UL44 from HSV-2
Gene Name	UL44 from HSV-2
Sequence Strain (Species/Organism)	Human alphaherpesvirus 2
NCBI Gene ID	1487331
NCBI Protein GI	820945196
Locus Tag	HHV2p31
Genbank Accession	KX574886
Protein Accession	YP_009137196
Taxonomy ID	10310
Gene Starting Position	97014
Gene Ending Position	99335
Gene Strand (Orientation)	+
Protein Name	envelope glycoprotein C
Protein pI	9.89
Protein Weight	47108.15
Protein Length	480
Protein Note	envelope glycoprotein C; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment
DNA Sequence	>NC_001798.2:97014-99335 Human herpesvirus 2 strain HG52, complete genome CATGGCCCTTGGACGGGTGGGCCTAGCCGTGGGCCTGTGGGGCCTGCTGTGGGTGGGTGTGGTCGTGGTG CTGGCCAATGCCTCCCCCGGACGCACGATAACGGTGGGCCCGCGGGGGAACGCGAGCAATGCCGCCCCCT CCGCGTCCCCGCGGAACGCATCCGCCCCCCGAACCACACCCACGCCCCCCCAACCCCGCAAGGCGACGAA AAGTAAGGCCTCCACCGCCAAACCGGCCCCGCCCCCCAAGACCGGGCCCCCGAAGACATCCTCGGAGCCC GTGCGATGCAACCGCCACGACCCGCTGGCCCGGTACGGCTCGCGGGTGCAAATCCGATGCCGGTTTCCCA ACTCCACCCGCACGGAGTTCCGCCTCCAGATCTGGCGTTATGCCACGGCGACGGACGCCGAGATCGGAAC GGCGCCTAGCTTAGAGGAGGTGATGGTAAACGTGTCGGCCCCGCCCGGGGGCCAACTGGTGTATGACAGC GCCCCCAACCGAACGGACCCGCACGTGATCTGGGCGGAGGGCGCCGGCCCGGGCGCCAGCCCGCGGCTGT ACTCGGTCGTCGGGCCGCTGGGTCGGCAGCGGCTCATCATCGAAGAGCTGACCCTGGAGACCCAGGGCAT GTACTACTGGGTGTGGGGCCGGACGGACCGCCCGTCCGCGTACGGGACCTGGGTGCGCGTTCGCGTGTTC CGCCCTCCGTCGCTGACCATCCACCCCCACGCGGTGCTGGAGGGCCAGCCGTTTAAGGCGACGTGCACGG CCGCCACCTACTACCCGGGCAACCGCGCGGAGTTCGTCTGGTTCGAGGACGGTCGCCGGGTGTTCGATCC GGCCCAGATACACACGCAGACGCAGGAGAACCCCGACGGCTTTTCCACCGTCTCCACCGTGACCTCCGCG GCCGTCGGCGGCCAGGGCCCCCCGCGCACCTTCACCTGCCAGCTGACGTGGCACCGCGACTCCGTGTCGT TCTCTCGGCGCAACGCCAGCGGCACGGCATCGGTGCTGCCGCGGCCAACCATCACCATGGAGTTTACGGG CGACCATGCGGTCTGCACGGCCGGCTGTGTGCCCGAGGGGGTGACGTTTGCCTGGTTCCTGGGGGACGAC TCCTCGCCGGCGGAGAAGGTGGCCGTCGCGTCCCAGACATCGTGCGGGCGCCCCGGCACCGCCACGATCC GCTCCACCCTGCCGGTCTCGTACGAGCAGACCGAGTACATCTGCCGGCTGGCGGGATACCCGGACGGAAT TCCGGTCCTAGAGCACCACGGCAGCCACCAGCCCCCGCCGCGGGACCCCACCGAGCGGCAGGTGATCCGG GCGGTGGAGGGGGCGGGGATCGGAGTGGCTGTCCTTGTCGCGGTGGTTCTGGCCGGGACCGCGGTAGTGT ACCTCACCCACGCCTCCTCGGTGCGCTATCGTCGGCTGCGGTAACTCCGGGGCCGGGCCCGGCCGCCGGT TGTCTTCTTTTCCACCCCTTCCGTCCCCCGTACCCACCACACCCCACCCCACCCCCCCGCCGTCCCCCGG GCGTTATAAGCCGCCGCACTCGCTTTTCCCACCGGAAAATCCTCGGCCCGATCCGAACGGCGCACGCCGC GTGGGCTCCAAACGCCTCCGGAAGAGAGCGCCCCGCCCCGATATTCAAGCCCGCGGTGGTGCTATGGCTT TCCGTGCTTCGGGACCCGCCTACCAGCCCCTCGCCCCCGCGGCCTCCCCGGCGCGGGCTCGTGTTCCGGC CGTGGCCTGGATCGGCGTCGGAGCGATCGTCGGGGCCTTTGCGCTCGTCGCCGCGTTGGTTCTCGTACCC CCTCGGTCCTCGTGGGGACTCTCGCCGTGCGACAGCGGCTGGCAGGAATTCAACGCGGGATGCGTCGCGT GGGACCCCACCCCCGTCGAGCACGAGCAGGCGGTCGGCGGCTGCAGCGCGCCGGCCACCCTTATCCCCCG TGCGGCCGCCAAGCACCTGGCCGCTCTGACACGCGTCCAGGCGGAGAGATCGTCGGGTTACTGGTGGGTG AACGGAGACGGCATCCGGACCTGTCTGAGACTCGTCGACAGCGTCAGTGGCATCGACGAGTTTTGCGAGG AGCTCGCGATCCGCATATGCTACTACCCACGAAGCCCCGGCGGGTTTGTCCGCTTCGTAACTTCGATACG TAACGCCCTGGGGTTGCCGTGAGGCGCGCGTCCGACGGTCCCGCTTCTCGCCTCTCTTCTTCCCCCACCC CACCCACCGACCAACGACGGCGTTTGGCCAATACCCTCCTTTTTTCTTTTTCTCTTCCCCCCCCCCCCAA AAAAAACAATAA
Protein Sequence	>YP_009137196.1 envelope glycoprotein C [Human alphaherpesvirus 2] MALGRVGLAVGLWGLLWVGVVVVLANASPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKATK SKASTAKPAPPPKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTEFRLQIWRYATATDAEIGT APSLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSVVGPLGRQRLIIEELTLETQGM YYWVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDP AQIHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTG DHAVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPDGI PVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAVVLAGTAVVYLTHASSVRYRRLR
Molecule Role	Protective antigen
Molecule Role Annotation	Balb/c mice were immunized with either pgB-2 or pgC-2 plasmids intramuscularly (IM) or intradermally (ID). IM immunization of latently infected guinea pigs with a combined gB-2 and gC-2 plasmid vaccine significantly reduced the number of subsequent HSV-2 recurrences (Mester et al., 1999). Another study also found that antibodies produced by gC-2 immunization blocked the interaction between gC-2 and complement C3b, and passive transfer of gC-2 antibody protected complement-intact mice but not C3 knockout mice against HSV-2 challenge (Awasthi et al., 2011). Therefore, gC-2 antibody is effective, at least in part, because it prevents HSV-2 evasion from complement.
References

UL44 from HSV-2