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ICP27 from Herpes simplex virus type 2
Gene Name	ICP27 from Herpes simplex virus type 2
Sequence Strain (Species/Organism)	Herpes simplex virus type 2
VO ID	VO_0011100
NCBI Protein GI	124181
Other Database IDs	CDD:293457 CDD:283185
Taxonomy ID	10315
Gene Strand (Orientation)	?
Protein Name	mRNA export factor
Protein pI	7.52
Protein Weight	56538.03
Protein Length	697
Protein Note	Immediate-early protein IE63; Infected cell protein 27; VMW63; ICP27
Protein Sequence	>sp\|P28276.1\|ICP27_HHV2H RecName: Full=mRNA export factor; AltName: Full=Immediate-early protein IE63; AltName: Full=Infected cell protein 27; Short=ICP27; AltName: Full=VMW63 MATDIDMLIDLGLDLSDSELEEDALERDEEGRRDDPESDSSGECSSSDEDMEDPCGDGGAEAIDAAIPKG PPARPEDAGTPEASTPRPAARRGADDPPPATTGVWSRLGTRRSASPREPHGGKVARIQPPSTKAPHPRGG RRGRRRGRGRYGPGGADSTPKPRRRVSRNAHNQGGRHPASARTDGPGATHGEARRGGEQLDVSGGPRPRG TRQAPPPLMALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVMQDPF GGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKAMRDCVLRQENLI EALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFLQCYLKARGLCGLDDLCSRRRLS DIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGETMHFYIPGACMAGLIEILDTHRQECSSRVCEL TASHTIAPLYVHGKYFYCNSLF
Molecule Role	Protective antigen
Molecule Role Annotation	Particle-mediated DNA vaccination of mice with a DNA plasmid-encoding ICP27 resulted in the induction of ICP27-specific IFN-gamma and TNF-alpha production in Balb/c mice. When the DNA vaccine was supplemented with as little as 50ng of a vector encoding the A and B subunits of the Escherichia coli heat labile enterotoxin (LT), animals were profoundly protected from morbidity and mortality (Haynes et al., 2006).
Related Vaccines(s)	Herpes simplex virus type 2 DNA vaccine encoding ICP27
References

ICP27 from Herpes simplex virus type 2