VIOLIN: Vaccine Investigation and Online Information Network

HBVgp2 pre-S1/pre-S2/S
Gene Name	HBVgp2 pre-S1/pre-S2/S
Sequence Strain (Species/Organism)	Hepatitis B virus
VO ID	VO_0011095
NCBI Gene ID	944569
NCBI Protein GI	941241316
Locus Tag	HBVgp2
Genbank Accession	AF372622
Protein Accession	YP_009173869
Other Database IDs	CDD:109739
Taxonomy ID	10407
Gene Strand (Orientation)	?
Protein Name	large envelope protein
Protein pI	8.08
Protein Weight	41375.3
Protein Length	389
Protein Note	S gene product, put.surface antigen (AA 1-226)
Protein Sequence	>YP_009173869.1 large envelope protein [Hepatitis B virus] MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWDFNPNKDTWPDANKVGAGAFGLGFTPPHGGLLGWSPQA QGILQTLPANPPPASTNRQSGRQPTPLSPPLRNTHPQAMQWNSTTFHQTLQDPRVRGLYFPAGGSSSGTV NPVLTTASPLSSIFSRIGDPALNMENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTV CLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTS TGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLS PTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI
Molecule Role	Protective antigen
Molecule Role Annotation	Immunisation with a plasmid encoding the DHBV large (L) envelope protein (HBVgp2 pre-S1/pre-S2/S) induced a strong, specific, highly neutralising and long-lasting anti-preS humoral response in uninfected ducks. Importantly, maternal antibodies elicited by such DNA immunisation were vertically transmitted and protected progeny against viral challenge (Thermet et al., 2003).
Related Vaccines(s)	Hepatitis B DNA vaccine pCMV-S2.S encoding the HBV(ayw Strain) envelope protein.
References