VIOLIN: Vaccine Investigation and Online Information Network

S segment
Gene Name	S segment
Sequence Strain (Species/Organism)	Topografov virus
VO ID	VO_0011089
NCBI Protein GI	4757106
Other Database IDs	CDD:279218 GOA:Q9WMG3 InterPro: IPR002214 UniProtKB/TrEMBL: Q9WMG3
Taxonomy ID	83192
Gene Strand (Orientation)	?
Protein Name	N protein
Protein pI	5.8
Protein Weight	47447.65
Protein Length	487
Protein Note	Hantavirus nucleocapsid protein; pfam00846
Protein Sequence	>CAB42097.1 N protein [Topografov hantavirus] MSNLKDIQDEITRYEQQLIVARQKLRDAEKTVEVDPDDVNKNTLQARRQTVSALEDKLADFKRQLADHVS RQKMDEKPSDPTGIEPDDHLKERSSLRYGNVLDVNAIDIEEPSGQTADWFTIGVYIVSFTLPIILKALYM LSTRGRQTVKENKGTRIRFKDDSSFEDVNGIRRPKHLYVSMPTAQSTMKAEELTPGRFRTIVCGLFPAQI QARNIMSPVMGVIGFSFFVKDWPERIKNFLESKCPFIKPEVKPGAPAGEADFLSRNQIYFMRRQEVLEDN HIPDIDKLLEYASSGDPTAPDSIESPYAPWVFACAPDRCPPTCIYIAGMAELGAFFSILQDMRNTIMASK TVGTAEEKLKKKSSFYQSYLRRTQSMGIQLDQRIILLYMVEWGKEMVDHFHLGDDMDPDLRNLAQSLIDQ KVKEISNQEPLKI
Molecule Role	Protective antigen
Molecule Role Annotation	To investigate the ability of recombinant N (rN, nucleocapsid proteins) from different hantaviruses to elicit cross-protection, we immunized bank voles with rN from Puumala (PUUV), Topografov (TOPV), Andes (ANDV), and Dobrava (DOBV) viruses and subsequently challenged them with PUUV. All animals immunized with PUUV and TOPV rN were completely protected (de Carvalho Nicacio et al., 2002).
Related Vaccines(s)	Topografov virus N protein vaccine
References