VIOLIN: Vaccine Investigation and Online Information Network

NS2
Gene Name	NS2
NCBI Protein GI	AIO08073
Other Database IDs	CDD:427145
Taxonomy ID	1545857
Gene Strand (Orientation)	?
Protein Name	NS2
Protein pI	8.78
Protein Weight	15420.92
Protein Length	186
Protein Note	Respiratory synctial virus non-structural protein NS2; pfam03113
Protein Annotation	(Pei et al., 2021)NS2 inhibits host interferon (IFN) responses stimulated by RSV infection by targeting early steps in the IFN-signaling pathway.
Protein Sequence	>AIO08073.1 NS2 [Human respiratory syncytial virus MinFLC] MDTTHNDNTPQRLMITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLL HKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP
Molecule Role	Protective antigen
Molecule Role Annotation	(Pei et al., 2021)NS2 binding prevents RLR ubiquitination, a process critical for prolonged activation of downstream signaling. N terminus of NS2 is essential for binding to the RIG-I caspase activation and recruitment domains.
References