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Pla

Gene Name Pla
Sequence Strain (Species/Organism) Yersinia pestis CO92
VO ID VO_0010877
NCBI Gene ID 1172643
NCBI Protein GI 16082686
Locus Tag YPPCP1.07
Genbank Accession AL109969
Protein Accession NP_395233
3D structure: PDB ID 2X56
Taxonomy ID 214092
Plasmid No pPCP1
Gene Starting Position 6664
Gene Ending Position 7602
Gene Strand (Orientation) +
Protein Name outer membrane protease
Protein pI 6.25
Protein Weight 33320.09
Protein Length 312
Protein Note outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
DNA Sequence 
>NC_003132.1:6664-7602 Yersinia pestis CO92 plasmid pPCP1, complete sequence
AATGAAGAAAAGTTCTATTGTGGCAACCATTATAACTATTCTGTCCGGGAGTGCTAATGCAGCATCATCT
CAGTTAATACCAAATATATCCCCTGACAGCTTTACAGTTGCAGCCTCCACCGGGATGCTGAGTGGAAAGT
CTCATGAAATGCTTTATGACGCAGAAACAGGAAGAAAGATCAGCCAGTTAGACTGGAAGATCAAAAATGT
CGCTATCCTGAAAGGTGATATATCCTGGGATCCATACTCATTTCTGACCCTGAATGCCAGGGGGTGGACG
TCTCTGGCTTCCGGGTCAGGTAATATGGATGACTACGACTGGATGAATGAAAATCAATCTGAGTGGACAG
ATCACTCATCTCATCCTGCTACAAATGTTAATCATGCCAATGAATATGACCTCAATGTGAAAGGCTGGTT
ACTCCAGGATGAGAATTATAAAGCAGGTATAACAGCAGGATATCAGGAAACACGTTTCAGTTGGACAGCT
ACAGGTGGTTCATATAGTTATAATAATGGAGCTTATACCGGAAACTTCCCGAAAGGAGTGCGGGTAATAG
GTTATAACCAGCGCTTTTCTATGCCATATATTGGACTTGCAGGCCAGTATCGCATTAATGATTTTGAGTT
AAATGCATTATTTAAATTCAGCGACTGGGTTCGGGCACATGATAATGATGAGCACTATATGAGAGATCTT
ACTTTCCGTGAGAAGACATCCGGCTCACGTTATTATGGTACCGTAATTAACGCTGGATATTATGTCACAC
CTAATGCCAAAGTCTTTGCGGAATTTACATACAGTAAATATGATGAGGGCAAAGGAGGTACTCAGACCAT
TGATAAGAATAGTGGAGATTCTGTCTCTATTGGCGGAGATGCTGCCGGTATTTCCAATAAAAATTATACT
GTGACGGCGGGTCTGCAATATCGCTTCTG
Protein Sequence 
>NP_395233.1 outer membrane protease (plasmid) [Yersinia pestis CO92]
MKKSSIVATIITILSGSANAASSQLIPNISPDSFTVAASTGMLSGKSHEMLYDAETGRKISQLDWKIKNV
AILKGDISWDPYSFLTLNARGWTSLASGSGNMDDYDWMNENQSEWTDHSSHPATNVNHANEYDLNVKGWL
LQDENYKAGITAGYQETRFSWTATGGSYSYNNGAYTGNFPKGVRVIGYNQRFSMPYIGLAGQYRINDFEL
NALFKFSDWVRAHDNDEHYMRDLTFREKTSGSRYYGTVINAGYYVTPNAKVFAEFTYSKYDEGKGGTQTI
DKNSGDSVSIGGDAAGISNKNYTVTAGLQYRF
Molecule Role Protective antigen
Molecule Role Annotation Study evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Results indicated that one of the predominant antibody response of mice surviving pneumonic plague after treatment with antibiotics was to pla (Benner et al., 1999).
References