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IglC1
Gene Name	IglC1
Sequence Strain (Species/Organism)	Francisella tularensis subsp. tularensis SCHU S4
VO ID	VO_0011072
NCBI Gene ID	3191591
NCBI Protein GI	56708413
Locus Tag	FTT_1357c
Genbank Accession	AJ749949
Protein Accession	YP_170309
3D structure: PDB ID	2QWU
Taxonomy ID	177416
Gene Starting Position	1398637
Gene Ending Position	1399272
Gene Strand (Orientation)	-
Protein Name	intracellular growth locus subunit C
Protein pI	6.26
Protein Weight	21340.81
Protein Length	211
Protein Note	Similar to AAP58964.1 (Q7X3J5) IglC (23 kDa protein) from Francisella novicida (211 aa). BLAST Score = 405, Expect = e-112 Identities = 209/211 (99), Positives = 210/211 (99) Identical to FTT1712. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625
DNA Sequence	>NC_006570.2:1398637-1399272 Francisella tularensis subsp. tularensis SCHU S4 chromosome, complete genome ACTATGCAGCTGCAATATATCCTATTTTAGCAACTCCTTTATCTGTGCTAGCTGCGCAACATACTGGCAA ACTTCCTTGAGATGTTGTAAGACCATCTATAGATATAATATGATATCTCATTCCATCTTTTGAAACACCC ATAAGTTCTGTTGGCTCTATACTAATACTAAAAGCCTTAGCACTTATTGGATATAACTCTAAATTAGATA GATCTATCATAATACCCCATGCTTCATCAGTTTTATACTCTTGTTTTTTATTAGAATTACCTAACTTAAT TTTCATATCTGTAGCACTTGCTTGTAATATACTCGAAACTTTCTCTTCAATTTTAGTTCTAACATTTGAT TTAATTAGAACACCAAGAGTAATACTTATTGTTGGATTTATAGAGCCTGGCGTTATAGATAAACGTATTA CACTAGCAGCAGCTGTAGCCGAATCAGCTTTCGTGACATCCTCTCCACCATCTATAGCAACGATATTTTT ATCAAGTTTCTCCCCAGCTATAGTTAAAGAATCAATAAATAATCTACAATTAGGATGAGATCCTATACAT GCAGTAGGATCAGTTCTCACATGAATGGTCTCGCCACTTGTTACCTGTTGTCTTGTTATCATCTCACTCA TAATCA
Protein Sequence	>YP_170309.1 intracellular growth locus subunit C [Francisella tularensis subsp. tularensis SCHU S4] MIMSEMITRQQVTSGETIHVRTDPTACIGSHPNCRLFIDSLTIAGEKLDKNIVAIDGGEDVTKADSATAA ASVIRLSITPGSINPTISITLGVLIKSNVRTKIEEKVSSILQASATDMKIKLGNSNKKQEYKTDEAWGIM IDLSNLELYPISAKAFSISIEPTELMGVSKDGMRYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAA A
Molecule Role	Protective antigen
Molecule Role Annotation	Mice immunized with rLm/iglC were protected against lethal challenge with F. tularensis LVS administered by the intranasal route, a route chosen to mimic airborne infection, and, most importantly, against aerosol challenge with the highly virulent Type A F. tularensis SchuS4 strain (Jia et al., 2009).
Related Vaccines(s)	F. tularensis vaccine rLm/iglC
References

IglC1