VIOLIN: Vaccine Investigation and Online Information Network

Rho
Gene Name	Rho
Sequence Strain (Species/Organism)	Eimeria tenella
VO ID	VO_0011064
NCBI Protein GI	84043169
Other Database IDs	CDD:304416
Taxonomy ID	5802
Gene Strand (Orientation)	?
Protein Name	rhomboid-like protein
Protein pI	8.07
Protein Weight	26568.3
Protein Length	314
Protein Note	Rhomboid family; cl21536
Protein Sequence	>ABC50099.1 rhomboid-like protein [Eimeria tenella] MSDIESQRVLGAGIPRTGRLIDVAFPNISLDKSIVVITLAQIAVYIMSCAMSSAFEPTERVLYQLGATYG PGIRHLQAWRLIMPVFLHVGIVHLLFNVLFILHMGLDKEIKYGRTNFLILYFSSALIGNMFTVLMRPCSL AVGASTAGFGLVGSILAEILIVWHKLDERTRNMYTLDMTVFGALMILLSYGQTVDIWGHLGGFVCGFAVT CEFNKNIRDLPHWFDLAKNGTRTICFGVVALTLARVFLGLPLPMGCA
Molecule Role	Protective antigen
Molecule Role Annotation	Two recombinant Mycobacterium bovis BCG (rBCG) strains carrying the Eimeria tenella rhomboid gene (Rho) delivered by extrachromosomal vector pMV261 and integrative vector pMV361 were evaluated for their ability to protect chickens against E. tenella challenge. Chickens were immunized intranasal with BCG, rBCG pMV261-Rho, or rBCG pMV361-Rho twice at a 2-week interval. All the recombinant BCG immunized chickens developed specific immune responses, and there was a significant increases of the percentages of CD4(+) and CD8(+) cells compared to the control (P<0.05). Challenge experiments demonstrated that the two rBCG strains could provide significant protection against E. tenella challenge (Wang et al., 2009).
Additional Molecule Role	Protective antigen
Related Vaccines(s)	E. tenella vaccine rBCG pMV261-Rho , E. tenella vaccine rBCG pMV361-Rho
References

Rho