VIOLIN: Vaccine Investigation and Online Information Network

MIC2
Gene Name	MIC2
Sequence Strain (Species/Organism)	Eimeria tenella
VO ID	VO_0011063
NCBI Protein GI	225579627
Other Database IDs	CDD:115333
Taxonomy ID	5802
Gene Strand (Orientation)	?
Protein Name	microneme 2
Protein pI	4.13
Protein Weight	32481.77
Protein Length	390
Protein Note	Microneme protein Etmic-2; pfam06670
Protein Sequence	>ACN93990.1 microneme 2 [Eimeria tenella] MARALSLVALGLLFSLPPSSAVRTRVPGEDSFSPESGVLSGTDAPERRPIVPGLVEGNCGRLTVRNGPSV DETIKVTSAGWTKSERDFIVSLVADETRKVVQLRESEGASGASGPGPAPAEKPPSGQGSAEEAPKGEGGQ EKPSVPLIAVRIHGSGGDKGESAPQSAVLLYGNDESEPTEVPLETAAGPTTPLMVLITQQNPKEVEVRVL AWISTDATTGKGSWKENSVVVGSSLSGRDLTVNLGDCGPSSLRVYGSASADLVTVKEGMCEADDPELIAL TRPHTSAASPLPAEEGDVAQDAQQSAGAQQEAEAQEVGEPQQEAAAAEQGSSAAESDTQQSS
Molecule Role	Protective antigen
Molecule Role Annotation	Birds vaccinated with Eimeria tenella microneme recombinant gene (EtMIC2) and encoded protein developed protective immunity against infection by E. tenella as assessed by significantly increased body weight gain and decreased fecal oocyst shedding compared with non-vaccinated controls. Vaccination with the EtMIC2 gene also led to protective immunity against infection by E. acervulina, but not E. maxima (Ding et al., 2005).
Additional Molecule Role	Protective antigen
Related Vaccines(s)	E. tenella DNA vaccine EtMIC2
References