VIOLIN: Vaccine Investigation and Online Information Network

botA
Gene Name	botA
VO ID	VO_0010902
NCBI Protein GI	733429
Other Database IDs	CDD:285228 CDD:285226
Taxonomy ID	32630
Gene Strand (Orientation)	?
Protein Name	botulinum neurotoxin serotype A Hc fragment
Protein pI	9.45
Protein Weight	49259.71
Protein Length	524
Protein Note	based on Clostridium botulinum Type A neurotoxin sequence
Protein Sequence	>AAA80610.1 botulinum neurotoxin serotype A Hc fragment [synthetic construct] MARLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVIL KNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVV FKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIW IKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKG PRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSA LEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTL GCSWEFIPVDDGWGERPL
Molecule Role	Protective antigen
Molecule Role Annotation	A completely synthetic gene encoding fragment C, a approximately 50-kDa fragment, of botulinum neurotoxin serotype A was constructed from oligonucleotides. Mice given three subcutaneous vaccinations were protected against an intraperitoneal administration of 10^6 50% lethal doses (ID50) of serotype A toxin (Clayton et al., 1995).
References