VIOLIN: Vaccine Investigation and Online Information Network

FHc
Gene Name	FHc
VO ID	VO_0010901
NCBI Protein GI	166236883
Other Database IDs	CDD:285228 CDD:285226
Taxonomy ID	32630
Gene Strand (Orientation)	?
Protein Name	recombinant botulinum toxin F Hc domain
Protein pI	9.28
Protein Weight	47714.27
Protein Length	504
Protein Note	Clostridium neurotoxin, N-terminal receptor binding; pfam07953
Protein Sequence	>ABY86211.1 recombinant botulinum toxin F Hc domain [synthetic construct] MYFNKLYKKIKDNSILDMRYENNKFIDISGYGSNISINGDVYIYSTNRNQFGIYSSKPSEVNIAQNNDII YNGRYQNFSISFWVRIPKYFNKVNLNNEYTIIDCIRNNNSGWKISLNYNKIIWTLQDTAGNNQKLVFNYT QMISISDYINKWIFVTITNNRLGNSRIYINGNLIDEKSISNLGDIHVSDNILFKIVGCNDTRYVGIRYFK VFDTELGKTEIETLYSDEPDPSILKDFWGNYLLYNKRYYLLNLLRTDKSITQNSNFLNINQQRGVYQKPN IFSNTRLYTGVEVIIRKNGSTDISNTDNFVRKNDLAYINVVDRDVEYRLYADISIAKPEKIIKLIRTSNS NNSLGQIIVMDSIGNNCTMNFQNNNGGNIGLLGFHSNNLVASSWYYNNIRKNTSSNGCFWSFISKEHGWQ EN
Molecule Role	Protective antigen
Molecule Role Annotation	Purified FHc was used to vaccinate mice and evaluate their survival against challenge with active botulinum neurotoxin serotype F (BoNT/F). Mice that received one injection of 5 microg or two injections of >or=0.04 microg of FHc were completely protected (Yu et al., 2008).
Related Vaccines(s)	C. botulinum FHc protein vaccine
References