VIOLIN: Vaccine Investigation and Online Information Network

PhtD
Gene Name	PhtD
Sequence Strain (Species/Organism)	Streptococcus pneumoniae
NCBI Protein GI	WP_000700338
Other Database IDs	CDD:273578 CDD:309414
Taxonomy ID	1313
Gene Strand (Orientation)	?
Protein Name	pneumococcal histidine triad protein PhtD
Protein pI	5.29
Protein Weight	89912.36
Protein Length	936
Protein Note	streptococcal histidine triad protein; TIGR01363
Protein Sequence	>WP_000700338.1 pneumococcal histidine triad protein PhtD [Streptococcus pneumoniae] MKINKKYLAGSVAVLALSVCSYELGRHQAGQVKKESNRVSYIDGDQAGQKAENLTPDEVSKREGINAEQI VIKITDQGYVTSHGDHYHYYNGKVPYDAIISEELLMKDPNYQLKDSDIVNEIKGGYVIKVDGKYYVYLKD AAHADNIRTKEEIKRQKQERSHNHNSRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGNHF HYIPKSDLSASELAAAQAYWNGKQGSRPSSSSSHNANPAQPRLSENHNLTVTPTYHQNQGENISSLLREL YAKPLSERHVESDGLIFDPAQITSRTARGVAVPHGNHYHFIPYEQMSELEERIARIIPLRYRSNHWVPDS RPEEPSPQPTPKPSPSPQPAPNPQPAPSNPIDEKLVKEAVRKVGDGYVFEENGVSRYIPAKDLSAETAAG IDSKLAKQESLSHKLGTKKTDLPSSDREFYNKAYDLLARIHQDLLDNKGRQVDFEALDNLLERLKDVSSD KVKLVEDILAFLAPIRHPERLGKPNAQITYTDDEIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHM THSHWIKKDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNLQY TVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERPHSDNGFGNASDHVR KNKADQDSKPDEDKGHDEVSEPTHPESDEKENHAGLNPSADNLYKPSTDTEETEEEAEDTTDETEIPQVE NSVINAKIAEAEALLEKVTDSSIRQNAMETLTGLKSSLLLGTKDNNTISAEVDSLLALLKKSQPAPIQ
Molecule Role	Protective antigen
Molecule Role Annotation	Seven proteins induced protective responses, in terms of reduced lung burdens of the serotype 3 pneumococci. Three of the protective proteins were histidine triad protein family members.(Anderson et al., 2016) Vaccination with PhtD reduced BG7322 bacterial burdens in MEF at both 24 (p=0.05) and 48hpi (p=0.16).(Xu et al., 2017)
References

PhtD