VIOLIN: Vaccine Investigation and Online Information Network

GroEL
Gene Name	GroEL
Sequence Strain (Species/Organism)	Chlamydophila pneumoniae
NCBI Protein GI	WP_010883533
Other Database IDs	CDD:223535 CDD:295468
Taxonomy ID	83558
Gene Strand (Orientation)	?
Protein Name	chaperonin GroEL
Protein pI	5.03
Protein Weight	54952.93
Protein Length	584
Protein Note	Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; COG0459
Protein Sequence	>WP_010883533.1 chaperonin GroEL [Chlamydia pneumoniae] MSEQEKLSNYNADKKLFSGIDKLFQIVKGSYGPKQSLSPTSFFKERGFYAISQTELSNSYENLGVDFAKA MVNKIHKEHSDGATTGLILLHAILQESYAALEKGISTHKLIASLKLQGEKLQEALQQQSWPIKDALKVRN IIFSSLHMPTIADHFYNAFSVVGPEGLISITKERENDKTSMDVFQGFKIPAGYASTYFVSDTASRLTRIA HPLILITDRKISMIHSLLPLLQEISEQNQHLIIFCEDIDPDVLATLVVNKLQGLLQVTVVTIPQLSTTNQ ELAEDIALFTGTHICPCQEASHVLAPEMVTLGSCLSIEISESQTTLIGGLHIPEVLTLKTRQLAEEIRTT SCLETKKRLIKSTNRLQSSVAILPTDEDNEPLYTLALKIMESALSRGYVPGGGVALFYASLTLGTPKDDA DENSIAISLLQKACCAPLKLLATNADLDGDAVIAKLSSLGTTSLGISVFSREIEDLIAGGILDSLATTST ILAQALDTAILVLSSKILILENQYEISTL
Molecule Role	Protective antigen
Molecule Role Annotation	Immunization of mice with a single construct containing multiple epitopes derived from ApoB100, hHSP60 and Cpn was more effective in reducing early atherosclerotic lesions.(Lu et al., 2012) Immunization with pmomp or phsp60 showed 1.2–1.5 log reduction in the mean lung bacterial counts after the challenge.(Penttilä et al., 2000)
Related Vaccines(s)	C. pneumoniae DNA vaccine pHSP-60
References