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cagA

Gene Name cagA
Sequence Strain (Species/Organism) Helicobacter pylori
NCBI Protein GI WP_130778457
Other Database IDs CDD:302624
Taxonomy ID 210
Gene Strand (Orientation) ?
Protein Name type IV secretion system oncogenic effector CagA
Protein pI 9.36
Protein Weight 124904.51
Protein Length 1277
Protein Note S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173
Protein Sequence 
>WP_130778457.1 type IV secretion system oncogenic effector CagA [Helicobacter pylori]
MVNETIDQTTTPDQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYA
NKAIKNPTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIR
NFMENIIQPPISDDKEKAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKVRQEAEKNEEPAGGDWLD
IFLSFVFNKKQSSDLKETLNQEPRPDVEQNLATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEG
VADKDPNYKFNQLLIHNNALSSVLMGSHSSIEPEKVSLLYGDNGGPEARHDWNATVGYKNQQGSNVATLI
NAHLNNGSGLVIAGNENGIKNPSFYLYKEDQLTGLKQAMSQEEIQNKVDFMEFLAKNNAKLDNLSEKEKE
KFQTEIGNFQKDRKAYLDALGNDHIAFVFKKDPKHLALVTEFGNGEVSYTLKDYGKKQDKALDGETKTTL
QGNLKYDGVMFVNYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDK
LWAKGLSPQEANKLIKDFLNSNKEMVGKVLNFNKAVAGAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVA
KKLESRNDNKNRMEAKAQANSQKDKIFALINQEASKEARAVAFDPNLKGIRSELLDKLENINKNLKDFGK
SFDELKNGKNNDFSKAEETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLEN
SIKDVIINQKITDKVDNLNQAVSETKLTGNFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNG
LSKAEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNNTEPIYAQVNKKKAGQATSPEESVYAQVAKKVS
VKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFDEANQVGFPLRRSAGVNDL
SKVGLSREQELTRRIGDLNQAVSEAKTGHFGNLEQKIDELKDSTKKNALKLWVESAKQVPTGLQAKLDNY
ATNSHTRINSNVQSGAINEKATGMLTQKNPEWLKLVNDKVVAHNVGSAPLSDYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTTKSGFQKS
Molecule Role Protective antigen
Molecule Role Annotation Compared to non-immunized mice, immunization with Epivac alone or with a Th1 adjuvant significantly reduced H. pylori colonization, and better protection was observed when an adjuvant was used (Li et al., 2012).
Related Vaccines(s) Epivac vaccine
References