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US7

Gene Name US7
Sequence Strain (Species/Organism) Bovine alphaherpesvirus 1
VO ID VO_0011042
NCBI Gene ID 4783432
NCBI Protein GI 9629887
Locus Tag BoHV1_gp127
Genbank Accession KU198480
Protein Accession NP_045371
Taxonomy ID 10320
Gene Starting Position 120286
Gene Ending Position 121435
Gene Strand (Orientation) +
Protein Name envelope glycoprotein I
Protein pI 9.63
Protein Weight 37115.17
Protein Length 382
Protein Note gD family
DNA Sequence 
>NC_001847.1:120286-121435 Bovine herpesvirus 1, complete genome
GATGCGGTGCCTGTTGCTCTGGATGGTGGTGCTGGCCGCGCGAGCGGCGCCCGCTCGCAGCCTTGTGTAT
CGCGGCGAGGCAGTCGGCCTGCGCGCGGACGGCCCCGTAGCGTTCGCTGTCCACCCGACCGACGCAACGC
TCGCGCTGCGGGGCCGGCTGATTTTCCTGGAACACCAGCTCCCGGCCGGGCGGCGCTACAACGGGACCGT
CGAGCTGCTGCGCTACCACGCCGCGGGCGACTGCTTCGTTATGCTGCAGACGACCGCGTTCGCCTCCTGC
CCGCGCGTCGCGAACGACGCCTTTCGCTCCTGCCTGCACGCCGACACGCGCCCCGCTCGCAGCGAGCGGC
GCGCGAGCGCCGCGGTCGAAAACCACGTGCTCTTCTCCATCGCCCATCCGCGCCCAATAGACTCAGGGCT
CTACTTTCTGCGCGTCGGCATCTACGGCGGCACCGCGGGCAGCGAGCGCCGCCGAGACGTCTTTCCCTTG
GCCGCGTTTGTACACAGCTTCGGTGAGCCCGGAGACCCAGAGGCCGCGGCCGCGCACCCCGGCGCCGTCG
AGGCAGTCGCGACCCGCTGCGAGCGGGGCCTCGACGCCAGCTCGGCGAGCCTCTACGACCGCGCGCTGGC
GGCGTTCCCCGCAGGCGCCGCCACCACGCCCGGCCCCACCGCGAGCAGCGGGAGCGGGGCCGCGACGCCG
GAGAGGGTCGACGAGACGACGGAAGTCAAGGCCGCGACGAGAGCGGGCTCGGCGTTTGCCCTCACCACGC
CCCCGGCCGGCCTGACCGCCAGCCCCGCCGCCAGCCCCTCCCGTGCCTTTAGCGCGGCCGCCCCGGCCGC
CGCTGCGCAGCCGGCCGGAGACACGCCCGCTCGCTTCCGGCGCCAACTGGCGTCGATCCTAGTGCCTCTG
TGCGTGCTGGTGCTGCTGCTGCTTGCGCTCTGCGCCGCGACGGTAAACTGCGCGCTGCGCCGCCGCCTGC
TGCCGTGCTCTCGGCGCGTTTACAAGCCGCGGACGTGCGCGACATGCGGGAGCGGCACTTGCGCGGGGCG
GCCCCCCTGCCGCGGCGCGGCACCGAGCGCCCCAGCCACCGTCGTGGCACTGGGCTCCCGGCCAAAGGCG
CCCCCCCTCGCCACCATCAGCGAAGAATAA
Protein Sequence 
>NP_045371.1 envelope glycoprotein I [Bovine alphaherpesvirus 1]
MRCLLLWMVVLAARAAPARSLVYRGEAVGLRADGPVAFAVHPTDATLALRGRLIFLEHQLPAGRRYNGTV
ELLRYHAAGDCFVMLQTTAFASCPRVANDAFRSCLHADTRPARSERRASAAVENHVLFSIAHPRPIDSGL
YFLRVGIYGGTAGSERRRDVFPLAAFVHSFGEPGDPEAAAAHPGAVEAVATRCERGLDASSASLYDRALA
AFPAGAATTPGPTASSGSGAATPERVDETTEVKAATRAGSAFALTTPPAGLTASPAASPSRAFSAAAPAA
AAQPAGDTPARFRRQLASILVPLCVLVLLLLALCAATVNCALRRRLLPCSRRVYKPRTCATCGSGTCAGR
PPCRGAAPSAPATVVALGSRPKAPPLATISEE
Molecule Role Protective antigen
Molecule Role Annotation Immunization of calves with truncated gpI (US7) protein induced gpI-specific nasal IgA, IgG1, serum neutralizing antibodies and gpI-specific peripheral lymphocyte proliferation. All immunized calves were protected from clinical disease after BHV-1 challenge. Further, nine of ten immunized calves had no intranasal viral shedding (Gao et al., 1994).
Related Vaccines(s) Bovine herpesvirus 1 GPI protein vaccine
References