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YbgF

Gene Name YbgF
Sequence Strain (Species/Organism) Rickettsia rickettsii
NCBI Protein GI KDO03483
Taxonomy ID 1462938
Protein Name tol-pal system protein YbgF
Protein pI 9.31
Protein Weight 27655.66
Protein Length 312
Protein Note predicted cleavage at residue 19
Protein Sequence 
>KDO03483.1 tol-pal system protein YbgF [Rickettsia buchneri]
MKLIVLLFTFLFSMVSFGESETIKGKPLKYAANNDFENRLDEQEQEIRRLIGKVEVLQHKIDMLTQNSNI
PNQEENTEVLEAGDSKKQDVFDIALLKDMPDNVPKKPIAVNKDIAPDKQAYDLALAAYKDNKLTEAKDKF
KNFIQKYPNSSLISNAYFWYGECFFKQKDYNGAAVNYLKGYKELPKGAKSSDGLLKLALSLGELKKTQEA
CNMLAKFDKEFSTNRTAASKKMAEDTKIKFGCKNK
Molecule Role Protective antigen
Molecule Role Annotation An in vitro neutralization test revealed that sera from mice immunized with GWP (six nucleotide sequences encoding the immunodominant peptides from Adr2, YbgF and OmpB) reduced R. rickettsii adherence to, and invasion of, vascular endothelial cells(Wang et al., 2017).

The results indicated that proliferation and interferon (IFN)-γ secretion of CD4(+) or CD8(+) T cells in R. rickettsii-infected mice were significantly greater than in uninfected mice after stimulation with rYbgF. YbgF is a novel protective antigen of R. rickettsii (Gong et al., 2015).
References