VIOLIN: Vaccine Investigation and Online Information Network

tpf1
Gene Name	tpf1
Sequence Strain (Species/Organism)	Treponema pallidum
NCBI Protein GI	WP_010882482
Other Database IDs	CDD:223854 CDD:153102
Taxonomy ID	160
Gene Strand (Orientation)	?
Protein Name	DNA starvation/stationary phase protection protein
Protein pI	5.02
Protein Weight	18954.12
Protein Length	269
Protein Note	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism, Defense mechanisms]; COG0783
Protein Sequence	>WP_010882482.1 DNA starvation/stationary phase protection protein [Treponema pallidum] MNMCTDGKKYHSTATSAAVGASAPGVPDARAIAAICEQLRQHVADLGVLYIKLHNYHWHIYGIEFKQVHE LLEEYYVSVTEAFDTIAERLLQLGAQAPASMAEYLALSGIAEETEKEITIVSALARVKRDFEYLSTRFSQ TQVLAAESGDAVTDGIITDILRTLGKAIWMLGATLKA
Molecule Role	Protective antigen
Molecule Role Annotation	immunization with the r4D Ag alters the course of experimental syphilis in a manner consistent with previously defined parameters of partial protection. (Borenstein et al., 1988) The reactivities of TpF1 with syphilitic sera were proportional to the titers of the T. pallidum particle agglutination (TPPA) assay. These data indicate that the recombinant protein TpF1 is a highly immunogenic protein in human and rabbit infections and a promising marker for the screening of syphilis.(Jiang et al., 2013)
References