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ptxB
Gene Name	ptxB
Sequence Strain (Species/Organism)	Bordetella pertussis
VO ID	VO_0011037
NCBI Protein GI	225311180
Other Database IDs	CDD:308828 CDD:280986 GOA:C0MPK7 InterPro: IPR003899 InterPro: IPR005138 InterPro: IPR008992 InterPro: IPR016187 InterPro: IPR020063 UniProtKB/TrEMBL: C0MPK7
Taxonomy ID	520
Gene Strand (Orientation)	?
Protein Name	pertussis toxin subunit 2 precursor
Protein pI	8.37
Protein Weight	23698.772
Protein Length	302
Protein Note	Aerolysin/Pertussis toxin (APT) domain; pfam03440
Protein Sequence	>CAX52304.1 pertussis toxin subunit 2 precursor [Bordetella pertussis] MPIDRKTLCHLLSVLPLALLGSHVARASTPGIVIPPQEQITQHGGPYGRCANKTRALTVAELRGSGDLQE YLRHVTRGWSIFALYDGTYLGGEYGGVIKDGTPGGAFDLKTTFCIMTTRNTGQPATDHYYSNVTATRLLS STNSRLCAVFVRSGQPVIGACTSPYDGKYWSMYSRLRKMLYLIYVAGISVRVHVSKEEQYYDYEDATFET YALTGISICNPGSSLC
Molecule Role	Protective antigen
Molecule Role Annotation	BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model. These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge (Bruss and Siber, 2002).
Related Vaccines(s)	B. pertussis PTx protein vaccine
References