VIOLIN: Vaccine Investigation and Online Information Network

tprF
Gene Name	tprF
Sequence Strain (Species/Organism)	Treponema pallidum
NCBI Protein GI	AGF43527
Other Database IDs	CDD:280810 CDD:280819
Taxonomy ID	491079
Gene Strand (Orientation)	?
Protein Name	TprF
Protein pI	8.2
Protein Weight	63453.71
Protein Length	683
Protein Note	Major Outer Sheath Protein N-terminal region; pfam02707
Protein Sequence	>AGF43527.1 TprF [Treponema pallidum subsp. pertenue str. CDC2] MGRQVMQAGVLAGMVCAASGYAGVLTPQVSGTAQLQWGIAFQKNPHTVPGEHTHGFRTTNSLTISLPLVS KHTHTRRGEARSGVWAQLQLKDLAVELASSKSSTALSFTKPTASFQATLHCYGAYLTVGTSPSCVVNFAQ LWKPFVTRAYSEKDTRYAPGFSGSGAKLGYQAHNVGNSGVDVDIGFLSFLSNGAWDSTDTTHSKYGFGAD ATLSYGVDRQRLLTLELAGNATLEQHYRKGTEDSTNENKTALLWGVGGRLTLEPGAGFRFSFALDAGNQH QSNADADCRLPATGSSREKFDRAFDALRVEQYRVKDKYLEFLLGQMAESSILERVGLALTLQDGTLVSTL TKVATDSGDWFIQMALVKLLPQRAQAEQGLREIVAPSQSDIVLIMLLTWLERARLDRFNADALLTAQWTY VSAGLYGATAGTNVFGKRVLPALQSWHFDFAGFLKLETKSGDPYTHLLTGLNAGVEARVYIPLTYIRYRN NGGYPLNGVVPPGTINMPILGKAWCSYRIPLGSHAWLTPHTSVLGTTNRFNVINPAYTLLNERALQYQVG LTFSPFEKVELSAQWEQGVLADAPYMGIAESKWSERYFGTFICGVNVGW
Molecule Role	Protective antigen
Molecule Role Annotation	These results demonstrate that epitopes in fragment 1 are recognized by T cells and antibodies during infection and that immunization with this portion of TprK most effectively attenuates syphilitic lesion development.(Morgan et al., 2002) N-terminal conserved region of TprF elicits strong T-cell responses during infection with different T. pallidum subsp. pallidum isolates(Sun et al., 2004)
References