VIOLIN: Vaccine Investigation and Online Information Network

cpn60
Gene Name	cpn60
Sequence Strain (Species/Organism)	Bordetella pertussis
VO ID	VO_0011035
NCBI Protein GI	968920
Other Database IDs	CDD:234573 CDD:239460
Taxonomy ID	520
Gene Strand (Orientation)	?
Protein Name	Cpn60 (GroEL)
Protein pI	4.81
Protein Weight	52145.9
Protein Length	605
Protein Note	chaperonin GroEL; Reviewed; PRK00013
Protein Sequence	>AAA74967.1 Cpn60 (GroEL) [Bordetella pertussis] MAAKQVLFADEARVRIVRGVNVLANAVKTTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENIG AQLVKDVASKTSDNAGDGTTTATVLAQAVVQEGLKYVAAGFNPIDLKRGIDKAVAAAVEELKKLSKPVTT SKEIAQVGSISANSDASIGQIIADAMDKVGKEGVITVEDGKSLENELDVVEGMQFDRGYLSPYFINSPEK QVAALDDPYVLIYDKKVSNIRDLLPVLEQVAKSSRPLLIIAEDVEGEALATLVVNNIRGILKTTAVKAPG FGDRRKAMLEDIAILTGGTVISEETGMSLEKATLQDLGQAKRIEVAKENTTIIDGAGDGKSIEARVKQIR AQIEEATSDYDREKLQERVAKLAGGVAVIRVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALL RAKQAITGLKGDTADQNAGIKLILRAVEEPLRTIVTNAGDEASVVVNTVLNGKGNYGYNAATGEYGDLVE QGVLDPTKVTRTALQNAASVASLLLTAEAAVVELMENKPAAAPAMPGGMGGMGGMDF
Molecule Role	Protective antigen
Molecule Role Annotation	A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal alpha-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge (Cainelli et al., 2007).
Related Vaccines(s)	B. pertussis Cpn60 protein vaccine
References

cpn60