VIOLIN: Vaccine Investigation and Online Information Network

pYV0055
Gene Name	pYV0055
Sequence Strain (Species/Organism)	Yersinia pseudotuberculosis IP 32953
VO ID	VO_0011016
NCBI Gene ID	2952948
NCBI Protein GI	51593897
Locus Tag	pYV0055
Genbank Accession	BX936399
Protein Accession	YP_068464
Taxonomy ID	273123
Plasmid No	pYV
Gene Starting Position	37489
Gene Ending Position	38694
Gene Strand (Orientation)	-
Protein Name	yopB; Yop targeting protein
Protein pI	7.3
Protein Weight	38322.89
Protein Length	401
Protein Note	similar to Y. pestis YPCD1.29c
DNA Sequence	>NC_006153.2:37489-38694 Yersinia pseudotuberculosis IP32953 pYV plasmid, complete sequence CTTAAACAGTATGGGGTCTGCCGGCCAAATTATGCAGCATGTCACCTTTTGCATTAATCATCTGGAAAAT CAGTTCCATCACTTGTTGATGTGACTCTGACAAATGGGATAATTCTTCTTTGAGTCGGTCAATAATACTT TGTAACGCTGCCATGTCTGCCTTGTTCAAGGCCAAATCAGCGTTATTATGTTGTAAATCAGCTTGCTTTT TATTATTGATGGTCTGAGTTATTCCGCTGCCCACACCAACGGCGACTTGTGTTGCCTGTGATCCTGTACG GATTGCATGGCTCATTGTTAAACCAGCAAAACTGCCCCCTAATTTAGTCACTGCACTCCCGACAGTGTTT GATATGCCTGTCGAAATTTGGGCAACTTTGGCCGAAAACTCGGCTCCTTTAGCCGCAAGACTTGCGGTGT TAGCACCGAGTTTTGCGCCAATATTAGCCAGGCATTTTAGTGCCGAACCGCCAAAGGTCATTACGGTTGA AACTACAGTCAATGCGACTTCAATCGCAGTGAGTATCGGCCCTAATATTTTCATTGCCTCTTGGGATATC AGGCCATCTTCCGCCGCTTGTTTCACTGCCATATTCGCCATCCCAATTACGCCTGAGGCAACCATCATTG CACCGGCAACGGCTCCTACCCCTGAGGCCACCATGATGGCACCGACAATCACTGAGGCTATGGCGCTGAG CCAGCCAAAAATCTTTGATGCAATGCCGGATTTCTTGACTTGCTTGGCATTCTCTTCTGTTTCTTTGATT TTCTCTTGATTCTCTTCAATTTTCTTCATGTTTTGTTCATGAAGACGCTGAATATCAGCGATTTTTATGT CTTTGCGTACTTCTTCTAAATTAGAAACTAGCTTACCTAACTCAATCTCAAATGTATCAGGTGAAGCAAG CGTAAACTTCGTTAGCACTGAAACATAATTTGATATCAGTTGAGATCCTGCCGCGCCGCGGGTGACCGAC TCCAATAATTTAGTGACTTCTTGCTGTTGTCCTTCAGTAACTTGGCTGGCAACCACTGCTAGTGGTGCAG GGAGCTGTACGCCCTGAGAACTCACCCCGCCATTTTTATCCTTCAGTTCTCCCGCGACTTGTTGGGTCTG AAGGGGGGCGGGCGCTGGTGTCTCGACGTAGGGAAGTAGACTTCCAGTTACTGGCGTTGAGCGGTCATGG GTTATCAACGCACTCA
Protein Sequence	>YP_068464.1 yopB; Yop targeting protein (plasmid) [Yersinia pseudotuberculosis IP 32953] MSALITHDRSTPVTGSLLPYVETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQE VTKLLESVTRGAAGSQLISNYVSVLTKFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKI EENQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMMVASGVIGMANMAVKQ AAEDGLISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLAAKGAEFSAKVAQ ISTGISNTVGSAVTKLGGSFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKA DMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHTV
Molecule Role	Protective antigen
Molecule Role Annotation	Complexes of YopB (pYV0055), YopD, and YopE (BDE) secreted by Yersinia pseudotuberculosis were purified by affinity chromatography and used as immunogens to determine if antibodies to the translocon could provide protection against Y. pestis in mice. The YopB protein or a complex of YopB and YopD (BD) was purified and determined by vaccination to be immunogenic in mice. Mice actively vaccinated with BD or passively vaccinated with anti-BD serum were protected against lethal challenge with F1(-) Y. pestis (Ivanov et al., 2008).
References

pYV0055