VIOLIN: Vaccine Investigation and Online Information Network

HpmB
Gene Name	HpmB
Sequence Strain (Species/Organism)	Yersinia pestis CO92
VO ID	VO_0011013
NCBI Gene ID	1176539
NCBI Protein GI	218930726
Locus Tag	YPO3720
Genbank Accession	AL590842
Protein Accession	YP_002348601
Taxonomy ID	214092
Gene Starting Position	4156356
Gene Ending Position	4158041
Gene Strand (Orientation)	+
Protein Name	hemolysin activator protein
Protein pI	6.38
Protein Weight	60678.51
Protein Length	561
Protein Note	Similar to Serratia marcescens hemolysin activator protein precursor ShlB SW:HLYB_SERMA (P15321) (557 aa) fasta scores: E(): 0, 54.2% id in 565 aa, and to Proteus mirabilis hemolysin activator protein precursor HpmB SW:HLYB_PROMI (P16465) (561 aa) fasta scores: E(): 0, 49.0% id in 571 aa
DNA Sequence	>NC_003143.1:4156356-4158041 Yersinia pestis CO92 chromosome, complete genome TATGATTAGAAAACGTACTGCGTTATGGCTTGTACTCAGTACTGGCGCTCAAGCCGAGACGCCTTTGGCC ATAGAGACCCCATCTTCCATTAATGAATCTCGCCAGTCACTACAAAATAATGCCAAAGAAATTAATCAGC TAGTAGAAGAAAAACGCCACCAACAGATCACACAACACAACACCGGACAAAGTGAATTATCTCGTCCGGC CCCCCCTGCACCGGTGTTACCCGAAGATACGCAGTGCCTACCCATTAATGGCGTTTATATTCAGGGGATC ACCTTATTAACAGAGGATGATTTAAGTGAATTAAGTGCGATCCCTGAACAATGTATTCATCCTGATAATA TTAACCTTCTGACCCGTGAACTCACTCATATCTATATGGATAAAGGGTATATCACGGCGCGGATTCAATT TATTCCACCAGATGCTGACGGAAAATTAGGTCTGGATATTACCGAAGGGTTTGTCGAAGCGATTGATAGC ACGGACACCGGGTTAGATGGCGAGACGGTATTCCCGAATATGATCGGCAAGCCGCTCAATATTACTCGCC TTGATCAAGGACTGGACCAGGCAAACCGTTTGCCCTCAAATAAAGTCACCGTCGATATTCTGCCCGGAAC ACTACCCGGTGGTTCTATTCTTAAACTGCATAATACACCGTCAACGCCCTGGCATTTGACCACCTCGATG GACAATTACGGTAATAAAAATACCGGTAAATGGCTAAGTCGCAACGCCTTATCTTTCGATAATCCGTTGG GCTTATCGGATTCCGTCAGTATCAATATCAGCAATACCGTTGATCGCCCCCAACATAATTATAGCCGTGC TTACTCAATGTTTTATTCGGTCCCTTACGGTGCCTTGACCTTTAGTGGCTTTGGTAGTTATGCCGAATAC CGTTATCCAATGAAATTGCAGTTTAATACAGCCAAGTTACATGGAGAAACACAGCAACACGGTTTACGGG CAGATTATGTTTTCTATCGCGATCAAAGCCAGATTAATGGGCTAAGTGCGCAATTAACCTATAAACGGGC CAGTAATTATCTGAATGAAGAAAAAATTGCTATCAGCAGCCCGACGCTAACAATCTTTGAATTAGGCCTT AATCACCTGCACGTCCTGCCCATGGGCTTATTCAATATCAATGTCAGCCTTGAGCAGGGCTTGCCTTGGC TGGGCGCGGAGCGCTCAAATGGCCCATTAGCGAACTATCAAGATAGCCAATTCACTAAAGCTAAGACCTC AATTACCTCCAATCACTACTTTGCACTGTTTGATGATACCTATCTGTTCAGCAATCAATTTTATGGCCAG TACACCCGTGACCGGTTACCCGGCGTGGAATGGCTCAGCATCACTGACAGCAGTGCCATCCGTGGCTTTA GCCGCAATACCTTATCCGCCGACCAAGGCTGGTATTTACAAAACACCCTCTCCCGTCGTTTCACCTTGGG TGACGCCACGCTAACCCCTCGCGTAGGGCTTGATACGGGCCGTCTCCAGCAAAAACCACAGGGGTGGGTC AGCGCTATGGGGCTAAGCGCTGGCGTCAGCCTTAATTACCAGAATGCCACCTTGGATATAGAAGCCAGCC GTGGCCGGTTACTCTCCGGCCCATCGAAGATTAACGATCCAACACAAATTCTGGCGCGTTTTTCTTACCG CTTTTA
Protein Sequence	>YP_002348601.1 hemolysin activator protein [Yersinia pestis CO92] MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHNTGQSELSRPA PPAPVLPEDTQCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLLTRELTHIYMDKGYITARIQF IPPDADGKLGLDITEGFVEAIDSTDTGLDGETVFPNMIGKPLNITRLDQGLDQANRLPSNKVTVDILPGT LPGGSILKLHNTPSTPWHLTTSMDNYGNKNTGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRA YSMFYSVPYGALTFSGFGSYAEYRYPMKLQFNTAKLHGETQQHGLRADYVFYRDQSQINGLSAQLTYKRA SNYLNEEKIAISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAERSNGPLANYQDSQFTKAKTS ITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQNTLSRRFTLG DATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRLLSGPSKINDPTQILARFSYR F
Molecule Role	Protective antigen
Molecule Role Annotation	Using a mouse plague model, YPO3720 (hpmB) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).
References

HpmB