VIOLIN: Vaccine Investigation and Online Information Network

YPO0612
Gene Name	YPO0612
Sequence Strain (Species/Organism)	Yersinia pestis CO92
VO ID	VO_0011007
NCBI Gene ID	1173455
NCBI Protein GI	218927806
Locus Tag	YPO0612
Genbank Accession	CP009973
Protein Accession	YP_002345681
Taxonomy ID	214092
Gene Starting Position	672594
Gene Ending Position	673838
Gene Strand (Orientation)	+
Protein Name	sugar binding protein
Protein pI	5.11
Protein Weight	44490.69
Protein Length	414
Protein Note	Similar to Rhizobium meliloti putative trehalose/maltose binding protein ThuE TR:Q9R9Q7 (EMBL: AF175299) (423 aa) fasta scores: E(): 1.4e-08, 23.9% id in 427 aa, and to Thermotoga maritima hypothetical protein TM1120 TR:Q9X0K4 (EMBL: AE001770) (436 aa) fasta scores: E(): 5.9e-09, 22.3% id in 452 aa
DNA Sequence	>NC_003143.1:672594-673838 Yersinia pestis CO92 chromosome, complete genome TATGAAGATACTTTATTATATTGCCATCGCGATAGCCTCGCTGCCGCTTATGGCGGCCGAAAGGCTAGAA ATTATGGTGCCCAGCGGCAGCTATGTTTCTTTTATGCGTAATACCGTCACCCCTGAATTTAATAAGCTCT ATCCCGAGGTTAATTTAGTGGTATCCAATGACGAACAACTGGATACCCGAATGGCCGCCGGGGATAACCC CAATGTTTACATCGGTGTATTCGGCTATCAACCCGCCAAACTGGCGAAGCTTGGCAAGCTGGCGTATTTG GATAAATTCCCCGGTTTTGCCGAATTAAATGAACGTATCGATCCTCACTTCTTACGCGAAAACTTTGGCC GTACCTATTATATTCCGTGGAACGCCACCACCCAGATGATGATTTATAATAAGGAGCTATTTGCTGAGGC AGGCTTGGATCCTGAGCGCCCTCCAGCGACCTGGGATGAATTTTTACTGGCGGCCGAAAAGATCTCCGCC TTGCCCCCTCGCTCAGACGGTAGCAAAGTCTACGGCACGGTATTCTGGAATGATGTGCTGTCATTCGGCA GTTGGTACTGGAATCTGCTGGCACCCATGTATTACAACGTTAATCAGGGCCAGTATCAGTTGCTAAACCG CTACGGTACCGACATCGTATTCGACCGTCCCGACGCCAACATGGCGCAGTTTATGCGTACCATGCAGCAG GCGCAGCGCTTTGCGCCACTGACCATGGAAAAAAGCTTCTTCTCCCGTAATATCGGCATGTGGCTACAAT TCGGCTTCGGCTGGAAGGCCACCCTCTCGTCGGCGGCTGAACGCCCAATGGTGGTAGGCCAGGACGTGGC CATCGCCCCGATCCCGGTACAAACCAAGGGCGACATCCACTACTCGGTATTGGATGGTCGGGCCATCATG ATTTTCAAGGATGAGGCCAGGAAAGAGCAACTCAGTTGGGCGCTGCTCAACCTACTTATGCGCGACGATA TCAATCTACAGGCCAATATTGCCCTGGGTCAGCTCCCTACGTTGAAGGCGCTGCAAGATGCTCCCTATTT TCAGTCCGCAGAGGCACAGCCGTTCGTACAGCAACTACAACATGCGATCCTGAGTGAGCCTTTCGCCAAT GCGATGGAGGTGGCGAATATTATTCTCGCCAACTACAGCAAAGTGGTACTGAAAGGGGAAATATCCCCGG AACAAGCGGTTGCCACCTCGGCACAGGCCGCACGCCAACTGCTCAATGAACACTG
Protein Sequence	>YP_002345681.1 sugar binding protein [Yersinia pestis CO92] MKILYYIAIAIASLPLMAAERLEIMVPSGSYVSFMRNTVTPEFNKLYPEVNLVVSNDEQLDTRMAAGDNP NVYIGVFGYQPAKLAKLGKLAYLDKFPGFAELNERIDPHFLRENFGRTYYIPWNATTQMMIYNKELFAEA GLDPERPPATWDEFLLAAEKISALPPRSDGSKVYGTVFWNDVLSFGSWYWNLLAPMYYNVNQGQYQLLNR YGTDIVFDRPDANMAQFMRTMQQAQRFAPLTMEKSFFSRNIGMWLQFGFGWKATLSSAAERPMVVGQDVA IAPIPVQTKGDIHYSVLDGRAIMIFKDEARKEQLSWALLNLLMRDDINLQANIALGQLPTLKALQDAPYF QSAEAQPFVQQLQHAILSEPFANAMEVANIILANYSKVVLKGEISPEQAVATSAQAARQLLNEH
Molecule Role	Protective antigen
Molecule Role Annotation	Using a mouse plague model, YPO0612 may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).
References

YPO0612