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YPMT1.84 (F1 capsule antigen)
Gene Name	YPMT1.84 (F1 capsule antigen)
Sequence Strain (Species/Organism)	Yersinia pestis CO92
VO ID	VO_0011004
NCBI Gene ID	1172839
NCBI Protein GI	16082876
Locus Tag	YPMT1.84
Genbank Accession	AL117211
Protein Accession	NP_395430
Taxonomy ID	214092
Plasmid No	pMT1
Gene Starting Position	85949
Gene Ending Position	86461
Gene Strand (Orientation)	+
Protein Name	F1 capsule antigen
Protein pI	4.63
Protein Weight	16375.93
Protein Length	170
DNA Sequence	>NC_003134.1:85949-86461 Yersinia pestis CO92 plasmid pMT1, complete sequence TATGAAAAAAATCAGTTCCGTTATCGCCATTGCATTATTTGGAACTATTGCAACTGCTAATGCGGCAGAT TTAACTGCAAGCACCACTGCAACGGCAACTCTTGTTGAACCAGCCCGCATCACTCTTACATATAAGGAAG GCGCTCCAATTACAATTATGGACAATGGAAACATCGATACAGAATTACTTGTTGGTACGCTTACTCTTGG CGGCTATAAAACAGGAACCACTAGCACATCTGTTAACTTTACAGATGCCGCGGGTGATCCCATGTACTTA ACATTTACTTCTCAGGATGGAAATAACCACCAATTCACTACAAAAGTGATTGGCAAGGATTCTAGAGATT TTGATATCTCTCCTAAGGTAAACGGTGAGAACCTTGTGGGGGATGACGTCGTCTTGGCTACGGGCAGCCA GGATTTCTTTGTTCGCTCAATTGGTTCCAAAGGCGGTAAACTTGCAGCAGGTAAATACACTGATGCTGTA ACCGTAACCGTATCTAACCAATA
Protein Sequence	>NP_395430.1 F1 capsule antigen (plasmid) [Yersinia pestis CO92] MKKISSVIAIALFGTIATANAADLTASTTATATLVEPARITLTYKEGAPITIMDNGNIDTELLVGTLTLG GYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQ DFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ
Molecule Role	Protective antigen
Molecule Role Annotation	Intranasal immunization with flagellin and the F1 antigen was protective against intranasal challenge with virulent Y. pestis CO92, with 93 to 100% survival of immunized mice. Lastly, vaccination of cynomolgus monkeys with flagellin and a fusion of the F1 and V antigens of Y. pestis induced a robust antigen-specific IgG antibody response (Honko et al., 2006).
Related Vaccines(s)	Y. pestis F1 antigen Vaccine with Flagellin
References

YPMT1.84 (F1 capsule antigen)