VIOLIN: Vaccine Investigation and Online Information Network

sopB
Gene Name	sopB
Sequence Strain (Species/Organism)	Salmonella enterica subsp. enterica serovar Typhimurium
VO ID	VO_0010999
NCBI Protein GI	54036439
Other Database IDs	CDD:283555
Taxonomy ID	99287
Gene Strand (Orientation)	?
Protein Name	Inositol phosphate phosphatase SopB
Protein pI	9.82
Protein Weight	60842.7
Protein Length	682
Protein Note	Effector protein SopB
Protein Sequence	>sp\|O30916.2\|SOPB_SALTY RecName: Full=Inositol phosphate phosphatase SopB; AltName: Full=Effector protein SopB MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKASN HSLHNLYNLQRDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQ QQDGLPAKEAHRFAAVAFRDAQVKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGK GVCSWDTKNIHHANNLWMSTVSVHEDGKDKTLFCGIRHGVLSPYHEKDPLLRHVGAENKAKEVLTAALFS KPELLNKALAGEAVSLKLVSVGLLTASNIFGKEGTMVEDQMRAWQSLTQPGKMIHLKIRNKDGDLQTVKI KPDVAAFNVGVNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGWVGEWLAQYPDNYEVVNTLAR QIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKREIISLHQTHMLSAP GSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLIT S
Molecule Role	Protective antigen
Molecule Role Annotation	The entire SopB and SifB genes were cloned into DNA vaccine vectors and were administered along with live attenuated Salmonella. It was found that SopB vaccination reduced the bacterial burden of organs by about 5-fold on day 4 and day 8 after challenge with virulent Salmonella and proved to be a more efficient vaccination strategy than live attenuated bacteria alone (Nagarajan et al., 2009).
Related Vaccines(s)	Salmonella DNA vaccine encoding SopB Protein
References

sopB