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ipaD
Gene Name	ipaD
Sequence Strain (Species/Organism)	Shigella flexneri 2a
VO ID	VO_0010996
NCBI Protein GI	22036352
3D structure: PDB ID	2J0O
Other Database IDs	CDD:297251
Taxonomy ID	42897
Gene Strand (Orientation)	?
Protein Name	IpaD
Protein pI	6.14
Protein Weight	23805.99
Protein Length	282
Protein Note	Invasion plasmid antigen IpaD; cl05827
Protein Sequence	>AAM89596.1 IpaD, partial (plasmid) [Shigella flexneri 2a] IRTTNQALKKELSQKTLTKTSLEEIALHSSQISMDVNKSAQLLDILSRNEYPINKDARELLHSAPKEAEL DGDQMISHRELWAKIANSINDINEQYLKVYEHAVSSYTQMYQDFSAVLSSLAGWISPGGNDGNSVKLQVN SLKKALEELKEKYKDKPLYPANNTVSQDQANKWLTELGGTIGKVSQKNRGYGVNINMPPIDNMLKSLDYL GGNGEVVL
Molecule Role	Protective antigen
Molecule Role Annotation	The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (IpaB, IpaC, and IpaD). Recent observations have indicated that the Ipa proteins (IpaB, IpaC, and possibly IpaD) form a multiprotein complex capable of inducing the phagocytic event which internalizes the bacterium. Researchers isolated a complex of invasins and LPS from water-extractable antigens of virulent shigellae. Western blot analysis of the complex indicates that all of the major virulence antigens of Shigella, including IpaB, IpaC, and IpaD, and LPS are components of this macromolecular complex. Guinea pigs (keratoconjunctivitis model) or mice (lethal lung model) immunized intranasally with purivied invasin complex (invaplex) on days 0, 14, and 28 and challenged 3 weeks later with virulent shigellae were protected from disease (P<0.01 for both animal models) (Turbyfill et al., 2000).
Related Vaccines(s)	S. flexneri Invaplex 24 Subunit Vaccine , S. flexneri Invaplex 50 Subunit Vaccine
References

ipaD