VIOLIN: Vaccine Investigation and Online Information Network

IpaC
Gene Name	IpaC
Sequence Strain (Species/Organism)	Shigella flexneri 2a
VO ID	VO_0010995
NCBI Protein GI	47056
Other Database IDs	CDD:185271 GOA:P18012 InterPro: IPR005427 UniProtKB/UniProt: P18012
Taxonomy ID	42897
Gene Strand (Orientation)	?
Protein pI	8.64
Protein Weight	40220.05
Protein Length	458
Protein Note	pathogenicity island 1 effector protein SipC; Provisional
Protein Sequence	>CAA33382.1 unnamed protein product (plasmid) [Shigella flexneri 2a] MLQKQFCNKLLLDTNKENVMEIQNTKPTQILYTDISTKQTQSSSETQKSQNYQQIAAHIPLNVGKNPVLT TTLNDDQLLKLSEQVQHDSEIIARLTDKKMKDLSEMSHTLTPENTLDISSLSSNAVSLIISVAVLLSALR TAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISDQKGALRKNLA TAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKFLGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQ RRTYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQA TNQLIQKLLNIIDSINQSKNSTASQIAGNIRA
Molecule Role	Protective antigen
Molecule Role Annotation	The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (IpaB, IpaC, and IpaD). Recent observations have indicated that the Ipa proteins (IpaB, IpaC, and possibly IpaD) form a multiprotein complex capable of inducing the phagocytic event which internalizes the bacterium. Researchers isolated a complex of invasins and LPS from water-extractable antigens of virulent shigellae. Western blot analysis of the complex indicates that all of the major virulence antigens of Shigella, including IpaB, IpaC, and IpaD, and LPS are components of this macromolecular complex. Guinea pigs (keratoconjunctivitis model) or mice (lethal lung model) immunized intranasally with purivied invasin complex (invaplex) on days 0, 14, and 28 and challenged 3 weeks later with virulent shigellae were protected from disease (P<0.01 for both animal models) (Turbyfill et al., 2000).
Related Vaccines(s)	S. flexneri Invaplex 24 Subunit Vaccine , S. flexneri Invaplex 50 Subunit Vaccine
References

IpaC