VIOLIN: Vaccine Investigation and Online Information Network

ipaB
Gene Name	ipaB
Sequence Strain (Species/Organism)	Shigella flexneri 2a
VO ID	VO_0010994
NCBI Protein GI	22036246
Other Database IDs	CDD:293143
Taxonomy ID	42897
Gene Strand (Orientation)	?
Protein Name	IpaB
Protein pI	7.76
Protein Weight	33839.83
Protein Length	371
Protein Note	Type III cell invasion protein SipB; pfam16535
Protein Sequence	>AAM89543.1 IpaB, partial (plasmid) [Shigella flexneri 2a] MHNVSTTTTGFPLAKILASTELGDNTIQAANDAANKLFSLTIADLTANKNINTTNAHSTSNILIPELKAP KSLNASSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQ INKLKNADSKIKDLENKINQIQTRLSELDPESPEKKKLSREEIQLTIKKDAAVKDRTLIEQKTLSIHSKL TDKSMQLEKEIDSFSAFSNTASAEQLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLALFQSLQE SRKTEMERKSDEYAAEVRKAEELNGV
Molecule Role	Protective antigen
Molecule Role Annotation	The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (IpaB, IpaC, and IpaD). Recent observations have indicated that the Ipa proteins (IpaB, IpaC, and possibly IpaD) form a multiprotein complex capable of inducing the phagocytic event which internalizes the bacterium. Researchers isolated a complex of invasins and LPS from water-extractable antigens of virulent shigellae. Western blot analysis of the complex indicates that all of the major virulence antigens of Shigella, including IpaB, IpaC, and IpaD, and LPS are components of this macromolecular complex. Guinea pigs (keratoconjunctivitis model) or mice (lethal lung model) immunized intranasally with purivied invasin complex (invaplex) on days 0, 14, and 28 and challenged 3 weeks later with virulent shigellae were protected from disease (P<0.01 for both animal models) (Turbyfill et al., 2000).
Related Vaccines(s)	S. flexneri Invaplex 24 Subunit Vaccine , S. flexneri Invaplex 50 Subunit Vaccine
References

ipaB