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SCFV

Gene Name SCFV
Sequence Strain (Species/Organism) Homo sapiens
NCBI Gene ID 652070
Genbank Accession DQ535056
Taxonomy ID 9606
Chromosome No 14
Gene Starting Position 53534950
Gene Ending Position 53539593
Gene Strand (Orientation) -
Protein Name single-chain Fv fragment
DNA Sequence 
>ref|NW_925561.1|:53534950-53539593 Homo sapiens chromosome 14 genomic contig, alternate assembly (based on Celera), whole genome shotgun sequence
TTTATGTATGCTGTGTTTCATAGTTCTCCTTGTAGGGATCTTTCACTTTGTTATCTGTATTCCCGGGCAT
TTCATTTTCTTTGTGGATACTGTAAGTCGAATAGGATTGTGTTCTTGATTATACTCTCAGCTCGGATGTG
GTTGGCTTATAGAAATGCTGGTAATTTTTGTCCATTGATTTTGTATCCTGACACTTTACTAAAGTTGTTT
ATTCTAGAATTATTTTGGCAGAGTTTTTAGGATTTTCTAGATATAGAATTATATCATCAGTGAAGATGGA
CGGATTGACTTCCTTTCCTATTTGGATGCTGTCTTAGTCCATTCTCGCACTGTAAAGAAACACCCGAGAC
TGGGTCATTTATAAAGATAAGTGTTTTAATTGGCTCATTTAGTATGATGTTAACTGTGGGTTTGTTGTAG
ATGGCTCTTATTCTGAAGTATGTTTCTTTGATGTCTAGTCTGTTGAGGGTTTTTATCATGAGTAGATGTT
AGATCCTATCGGAAGCTTTCTCAGCATCTATTGACATAATCATATGCTTTTTGCTTTTATTCTGTTTACA
TTGTGAATCAGAGTTACTGTGGATATTGAACGAGCCTTGCATCCCAGGGGTAAAGCCCACCTGACCATGA
TGTATCACATTTTAAAGTGCTTCTGGATTCAATTTGATGGTATTTTGTTGAGGACTTTCAGGTCTATGTT
CATCAGGACTATTGATCTCATATTTTTTTTGTCATTATGTCTCTCCTGATTTTGTGTGCCAAGAGCACAC
AGTAGAGAAAGGACAGTCTTTTCAATAATGGTGTAAAACTGGCATTCATATGCAAAAGAAATAAAATTAG
GCCTTCTCTAACTCCATATAAAAAAATCAACTAATAGGCCGCGCGCGGTGGCTCACGCCTGTAATCCCAG
CACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATGGAGACCACAGTGAAACCCCGTCTCTA
CTAAAAATACAAAAAAAAATTAGCTAGGCGCGGTGGCCAGCGCCTGTAGTCCCAGCTACTCGGAGGCTGA
GGCAGGAGAATGGCGTGAACTCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGC
CTGGGCTACAGAGCAAGACTCCGTCTCCCAAAAAAAAAAAAAATCAACTAAAAATGGACATAATACCTGA
AGCCATAAACTCATAAATGACATGGAGCAAAAAAAATTCCTGCCATTAATTCGGAACTGATTTCTTTGAA
TTTAATAACAAAGCACAGGAAAAACTATGTGCAATTATGGATCTGACAAGAAGTTCTGTCCAAATGTATA
AATAACCCATACACCTCAACAGCAAATAACAAATGAACTGATAAAAAAGGGCAAAAACCTGGATAATTTT
TTTCAGAAGATACATGCATGGCAAACAGAAAACGAAAAAGTTCTCAACATTCCTAATTATCAGAGGAATT
CAAATGAGAAGCACAATGCAATATCAACTCACACTAGTTAATATGGCTATTATCAGAAATGTAACAGATG
ACAAATGTTGGCAAGAATGTGGGGGAAAGGGAAATATCCTGTGGTAGGATTGGTTACTTGATAAGTTAAA
AATAAAGCTATCATATAATCTGGTGATCCCACTTCTTGTTATATATGCAAAGGAAATAAAATTACTTTGC
CAGAGACATGTTCATTGCAAGATTATTAATAATAGTGTAGATTTGTAAAATAATTTAATGACTGTAAATG
GATGAATGTATAAAGAAAATGTGTATACATACCTCTGTATTTTATTTGGCTTTGAAAAGAGGGAAATTCT
GACATTTGCAACAACACGGATGGGCCTGGAGGACATGATGCTGAGTTGAATAAGCCAGATGCAGAAAGAC
AAATGCTGCATGATCTCATTTACATGTGGGATCTAAAATATTCAAGCTCTTGAAAGCAGAGAGTAGAATA
GTGGGTCCCAGGACCTGGGAGGTGAGGGAAATTGGGTGATGTGTGTTAAATTGTACAGAGTTTCAGTTGT
GCAGGTTGGATGAGTTCTGGAGATCTAACGTACAGCAATGGTCCTATAGTTAATACTGTATTGTAAAAAT
GATTGTTGCTGAAAGGGTAGATCTTAGGTGTTCTCATCAGACACTCACTCATGCAGTAAATTAAAAAAAA
TAATAAAATGGTAGCGCTGTGAGGTGATAGAAATACAAATTACCTGACCACCATGCGTATTTCACAATGT
GTATCTGATATGGTTTGGATTTGTGTCCTGCCCCAAATCTCATGTTGTATTATAATCCCCAGTTGTGAAG
GGGTGACCTGGTGGGAGGTGACTGGGTCATGGAGTGGGTCTTTCATGAATGGTTTAGAACTGACTCCTGG
TGCTGTTCTCATGAAAATGTGTGAGTTCTCACAAGGGAATCCCCTTGAGGTTACTGTCCTGAGTCTGACT
GGAGAAGACTCACCAGGCACCCCTGAGCTTCCTCACGACTCTGATGCTGGTGACCATGGTTGAGGACCTT
TCATTCCCATAGGTGGCAATATACATATTGTGCATGTGAGAACGAGTCCTCATATACAATGATTAAAAAA
ATGTAGAGATGACATTGGTGGGCACAGAAATCTAAAATTAAAGAGTTTCCCTAGAGAAACTGTCAGAAGC
AGAGGAAGTCCCAAATCCTGACAGGAAACAAACCCCAGCCTCCATGTGCACCTGCTCTGGGGTTGACTCT
GATGAGTGGGTCCTGAGCGCCCCCTGCAGCTGATTTCCCCCAACGTTCCTGCAGGAGGTTTGTGTCTGGG
CTCACACTTCCGACCTCTCACAGTGTTTCTCACACAGTAATACACAGCCGTGTCCTCGGCCCTCAGGCTA
TTCGTTTGCAGATACAGGGTGTTCCTGGAATTGTCTCTGGAGATGATGAATCGGCCCTTCACAGAGTCTG
CATAGTGCGTCCTACTGCCATTCCAACTAACACCCGATACCCACTCCAGCCCCTTTCCTGGAGCCTGATG
GACCCAGTTCATGTCACTGTTACTGAAGGTGAATCCAGAGGCTGCACAGGAGAGTCTCAGGGATCCCCCA
GGCTGTACCAAGCCTCCCCCAGACTCCACCAGCTGCACCTCACACTGGACACCTGCAAACACAGAGACAC
CCTGGTCAGAAACTGCCACACAAATCCACTGTTTCTCTCACTCATGTCCACTCACTCAATATCCTTAGTT
CTTCATGAATCACCTTTTAAAATAGCAGCAAGAAAAACCCAGCTCAGCCCAAATTCCATGGTAATTTGTT
TGTTGCTGATGACAAAGTGGAAACACCTGAGAATCCCAGGGCTGGTGCTTCTCTCCCAGGGCTGCAGGGT
CAGGACTGGGCTGCTTTTTATCAGGAAAGGGGGGGCCCTATTTGCATGTCTCCTATTTCACAGCGAGCTC
TGAAGTGGGACACCTGAGGAGAGGACTGAGCCCAGAGTAATGAGAGTGAAACAACAAGCCTGAACAACTA
CAAATAAAGAAAAAAAAACACACTTGAACATATCAGAGTTGATGTCACAGAGCAAACATAAACTGTAAAT
TTGAGGAGATATAGCTTGGCAGGGAGACCCAGGATGCATATATGAGTGTGCCTGGGGAAGGTGCCGCTCC
ATGGCATTTAAGCTAACCTCAAAACATTTAGAGTTCCTTGAGGATGTACGCATTAATGGTGCTAGAGTGT
GAAGCTTCTAATGCCATGTGTTGTTGCAGGCTTTCCTTACGAAGTTGGGAAATATCCCAGATGACCACAC
ACTCACCCAAGGTGACCTCACACATCCCCAAGGTCACCTCACATATGCCCTGAATCACCTCACGCATCCC
CAATTTCACCTCACATGTGCCCTGAGTCACCTCACACATCCCCAGTGTCACCTTACACATCCTGCAGGTC
ACCTCACACATCCACAGGTCACCTCAACATCCCAGGTCACCGCACATATACCCCACATCACCTCAGACAC
ACCCTGGTCACCTCATACATACGTCAGGTCACCTCACGCTCACCCAAGGTCACCTCACACATCCCGCAGG
TCACCTCGTAAATCCCCCAGGTCACCACATACATGCACCAGTTCACCTCACACATTCCTCAGGCACTTCA
CACCTGCCCCTGTTCACCTCACACATCCCCCAGGTAACCTAACACATGCACCAGGTCACCTCACATGCAC
CCAGGTCACTGCACACATGCCCTTTGTCACCTCACACATGCCCCAGGTCACCTCACACATTCCCCATGTC
ACCTCAAACGGTCCCAGGTCACCATACACATTCCACAGGTCACCTCACATGTGCCCTAGGTGACTTCACC
TGTACCCACCTCACACATTTCCAGGTCCCCACAGATGCCCCAGGTAACCTCATACCTCCTTAGGTCACCT
CACACACACCCACATCACCACCAATCCCCGATGTCACCTGACATGTGCCCAAGTCACCTCACACACACCC
CCAGGTCACCTCACATCCATCCTGGATCACCTCACACTCACCCGAGGTCAGCTCACACATATCCCCCACG
TCACCTCACATGTGCCCCAAATCACCTTACATGCATCCACGTCACCTCACACTTGCTCTGTGTCACCTCA
CAAATCCCCCTGGCTTACCCGACA
Protein Sequence 
>CAA73499.1 single-chain Fv fragment, partial [Homo sapiens]
QVQLVQSGGGLVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTI
SRDNSKNTLYLQMNSLRAEDTAVYYCARDWGDSLDPWGKGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSP
STLSASIGDRVTITCRASEGIYRWLAWYQQKPGKAPKLLIYKASSLASRAPSRFSGSGSGTDFTLTISSL
QPDDFATYYCQQYSNYPLTFGGGTKLEIKR
Molecule Role Protective antigen
Molecule Role Annotation A scFv gene construct linked to the CH3 exon of the human IgG1 constant region was produced and tested its efficacy in inducing protective immunity against the mouse BCL1 lymphoma. The addition of an immunogenic domain linked to the scFv has proved essential for the induction of a protective immune response. Protection against tumor challenge was fully achieved with the complete scFv construct (Benvenuti et al., 2000).
References