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L1R from Monkeypox virus Zaire-96-I-16
Gene Name	L1R from Monkeypox virus Zaire-96-I-16
Sequence Strain (Species/Organism)	Monkeypox virus Zaire-96-I-16
VO ID	VO_0010871
NCBI Gene ID	928938
NCBI Protein GI	17974998
Locus Tag	MPXVgp085
Genbank Accession	AF380138
Protein Accession	NP_536512
Taxonomy ID	619591
Gene Starting Position	80280
Gene Ending Position	80738
Gene Strand (Orientation)	+
Protein Name	L1R
Protein pI	4.99
Protein Weight	17001.2
Protein Length	152
Protein Note	similar to Vaccinia virus strain Copenhagen J1R
DNA Sequence	>NC_003310.1:80280-80738 Monkeypox virus Zaire-96-I-16, complete genome AATGGATCACAACCAGTATCTCTTAACGATGTTCTTCGCAGATGATGATTCATTTTTTAAGTATTTTGCT AGTCAAGATGATGAATCTTCATTATCTGATATATTGCAAATCACTCAATATCTAGACTTTCTGTTATTAT TATTGATCCAATCAAAAAATAAATTAGAAGCTGTGGGTCATTGTTATGAATCTCTTTCAGAGGAATACAG ACAATTGACAAAATTCACAGACTCTCAAGATTTTAAAAAACTGTTTAACAAGGTCCCTATTGTTACAGAT GGAAGGGTCAAACTTAATAAAGGATATTTGTTCGACTTTGTGATTAGTTTGATGCGATTCAAAAAAGAAT CAGCTCTAGCTACCACCGCAATAGATCCTGTTAGATACATAGATCCTCGTCGTGATATCGCATTTTCTAA CGTGATGGATATATTAAAGTCGAATAAAGTTGAACAATA
Protein Sequence	>NP_536512.1 L1R [Monkeypox virus Zaire-96-I-16] MDHNQYLLTMFFADDDSFFKYFASQDDESSLSDILQITQYLDFLLLLLIQSKNKLEAVGHCYESLSEEYR QLTKFTDSQDFKKLFNKVPIVTDGRVKLNKGYLFDFVISLMRFKKESALATTAIDPVRYIDPRRDIAFSN VMDILKSNKVEQ
Molecule Role	Protective antigen
Molecule Role Annotation	It has previously been shown that a DNA subunit vaccine (4pox) based on four orthopoxvirus immunogens (L1R, B5R, A27L and A33R) can produce protective immunity against lethal orthopoxvirus challenges in mice and nonhuman primates. the immunogenicity of an L1R construct to which a tissue plasminogen activator signal sequence was placed in frame with the full-length L1R gene was tested. When the tPA-L1R construct was substituted for the unmodified L1R gene in the 4pox vaccine, given as a prime and single boost, animals were better protected from lethal challenge with vaccinia virus (VACV) (Golden et al., 2008).
Related Vaccines(s)	Smallpox DNA Vaccine
References

L1R from Monkeypox virus Zaire-96-I-16