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ireA
Gene Name	ireA
Sequence Strain (Species/Organism)	Escherichia coli CFT073
VO ID	VO_0010985
NCBI Gene ID	1037614
NCBI Protein GI	AMR36194
Locus Tag	c5174
Genbank Accession	AE014075
Protein Accession	NP_757022
Other Database IDs	CDD:139605
Taxonomy ID	562
Gene Starting Position	4935989
Gene Ending Position	4938037
Gene Strand (Orientation)	+
Protein Name	IreA
Protein pI	6.54
Protein Weight	71893.67
Protein Length	729
Protein Note	putative iron-regulated outer membrane virulence protein; Provisional
DNA Sequence	>NC_004431.1:4935989-4938037 Escherichia coli CFT073, complete genome TATGAAGAACAAATATATCATTGCTCCGGGCATTGCCGTGATGTGTTCTGCAGTTATATCATCAGGTTAT GCCAGTTCTGATAAAAAAGAAGATACGCTTGTTGTTACTGCCTCCGGGTTCACTCAGCAGCTCAGAAATG CCCCGGCCAGTGTCTCAGTCATTACTTCAGAACAACTGCAAAAAAAACCGGTTTCAGATCTGGTCGATGC AGTAAAAGATGTTGAAGGGATTAGTATCACTGGTGGGAATGAAAAACCGGATATCAGTATACGTGGTCTA AGTGGCGATTACACGCTGATTCTGGTCGATGGACGACGTCAGAGCGGTCGGGAATCCAGACCAAACGGCA GCGGCGGTTTTGAAGCCGGATTTATCCCTCCTGTGGAAGCAATTGAACGCATTGAAGTGATCCGTGGCCC TATGTCTTCCCTGTATGGTTCTGATGCCATCGGAGGGGTCATTAATATCATAACCAAACCAGTTAATAAC CAAACATGGGATGGCGTACTTGGACTTGGGGGGATTATTCAGGAACATGGGAAATTTGGTAACTCAACCA CAAATGACTTCTATCTGTCAGGCCCATTGATTAAGGATAAACTTGGTCTTCAGCTATATGGAGGAATGAA CTATCGCAAGGAAGATAGTATCTCTCAGGGAACACCGGCAAAAGATAATAAGAATATAACGGCAACGCTC CAGTTTACTCCGACTGAAAGCCAGAAGTTTGTTTTTGAATATGGAAAAAATAACCAGGTGCATACATTAA CACCTGGTGAGTCTCTCGATGCCTGGACTATGCGGGGAAATCTTAAACAACCAAACAGTAAAAGAGAAAC GCATAATTCACGTAGTCACTGGGTAGCAGCATGGAATGCCCAGGGCGAAATACTGCATCCTGAAATTGCT GTTTATCAGGAGAAAGTTATTCGTGAGGTTAAATCAGGTAAAAAAGATAAATATAATCATTGGGATCTTA ATTACGAGTCAAGAAAACCGGAAATAACCAACACAATCATAGATGCAAAAGTGACGGCATTTCTGCCGGA AAATGTACTGACCATCGGAGGTCAATTTCAGCATGCAGAGCTCCGTGATGACTCAGCCACGGGTAAAAAA ACGACAGAAACACAGTCTGTTTCAATTAAACAGAAAGCTGTTTTTATAGAAAATGAATATGCAGCAACGG ATTCTCTCGCCCTGACTGGAGGACTGCGTCTCGATAATCATGAAATCTATGGCAGTTACTGGAATCCAAG ATTGTACGCTGTTTATAACCTGACCGATAATCTCACACTCAAAGGGGGGATCGCAAAAGCATTTCGGGCT CCTTCAATTCGTGAGGTGAGTCCTGGATTTGGAACACTGACGCAGGGTGGTGCCTCTATTATGTATGGAA ACAGGGACCTGAAACCGGAGACCAGTGTAACCGAAGAGATCGGTATTATTTATAGTAATGATAGTGGTTT TTCGGCGAGCGCGACGCTGTTTAATACTGATTTTAAAAATAAGTTGACCAGTTACGATATAGGTACAAAA GATCCAGTCACCGGGTTAAACACTTTTATTTATGATAATGTAGGTGAGGCAAATATCAGAGGGGTGGAGC TTGCAACTCAGATTCCTGTGTATGATAAATGGCATGTATCTGCAAACTATACATTTACTGACTCTCGTCG AAAAAGTGATGACGAAAGTCTCAATGGCAAGTCGCTGAAAGGGGAACCTCTGGAAAGAACTCCCAGACAT GCAGCCAATGCAAAACTGGAATGGGATTACACTCAGGATATTACATTTTATTCATCTCTGAATTATACGG GAAAACAAATCTGGGCAGCACAAAGAAATGGTGCTAAGGTTCCCCGCGTTCGTAATGGATTCACATCTAT GGATATTGGTCTAAATTACCAGATTCTGCCAGACACGCTGATTAATTTTGCCGTTCTTAACGTCACAGAC AGAAAGAGCGAGGATATCGATACCATTGATGGTAACTGGCAGGTCGATGAAGGACGCCGTTATTGGGCTA ATGTAAGAGTATCCTTCTG
Protein Sequence	>AMR36194.1 IreA [Escherichia coli] MKNKYIIAPGIAVMCSAVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDA VKDVEGISITGGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGFEAGFIPPVEAIERIEVIRGP MSSLYGSDAIGGVINIITKPVNNQTWDGVLGLGGIIQEHGKFGNSTTNDFYLSGPLIKDKLGLQLYGGMN YRKEDSISQGTPAKDNKNITATLQFTPTESQKFVFEYGKNNQVHTLTPGESLDAWTMRGNLKQPNSKRET HNSRSHWVAAWNAQGEILHPEIAVYQEKVIREVKSGKKDKYNHWDLNYESRKPEITNTIIDAKVTAFLPE NVLTIGGQFQHAELRDDSATGKKTTETQSVSIKQKAVFIENEYAATDSLALTGGLRLDNHEIYGSYWNPR LYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEIGIIYSNDSGF SASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQIPVYDKWHVSANYTFTDSRR KSDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFYSSLNYTGKQIWAAQRNGAKVPRVRNGFTSM DIGLNYLILPDTLINFAVLNVTDRKSEDIDTIDGNWQVDEGRRYWANVRVSF
Molecule Role	Protective antigen
Molecule Role Annotation	Immunization with IreA protects against urinary tract colinization by E.coli CFT073 and reduces colinization by E.coli 536 in the bladder of CBA/J mice (Alteri et al., 2009). We demonstrated for IreA, antigen-specific serum IgG represents a strong correlate of protection in vaccinated mice (Mobley and Alteri, 2015).
Related Vaccines(s)	E. coli IreA protein vaccine
References

ireA