VIOLIN: Vaccine Investigation and Online Information Network

skp
Gene Name	skp
VO ID	VO_0010918
NCBI Nucleotide GI	4574245
NCBI Protein GI	4574246
Genbank Accession	AF109085
Protein Accession	AAD23967.1
Other Database IDs	CDD:225381 CDD:182724
Taxonomy ID	727
Gene Strand (Orientation)	?
Protein Name	outer membrane protein 26
Protein pI	7.75
Protein Weight	20936.21
Protein Length	264
Protein Note	Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones]; COG2825
DNA Sequence	>gi\|4574245\|gb\|AF109085.1\| Haemophilus influenzae NTHI-289 outer membrane protein 26 (skp) gene, complete cds ATGAAAAACATCGCAAAAGTAACCGCACTTGCTTTAGGTATTGCACTTGCTTCAGGCTATGCTTCCGCTG AAGAAAAAATTGCTTTCATTAATGCAGGTTATATTTTTCAACATCACCCAGATCGCCAAGCGGTAGCAGA TAAACTTGATGCTGAATTTAAACCTGTAGCTGAGAAATTAGCAGCAAGCAAAAAAGAAGTTGATGATAAA ATTGCTGCTGCTCGTAAAAAAGTAGAAGCAAAAGTTGCGGCTTTAGAAAAAGATGCACCTCGCTTACGTC AAGCTGATATTCAAAAACGCCAAGAAGAAATTAATAAATTAGGTGCGGCTGAAGATGCTGAATTACAAAA ATTAATGCAAGAACAAGATAAAAAAGTTCAAGAATTCCAAGCTCAAAATGAAAAACGTCAAGCTGAAGAA CGTGGTAAATTATTAGATAGCATTCAAACTGCGACAAATAATTTAGCAAGAGCAAAAGGTTATACTTATG TGCTTGATGCAAATTCAGTTGTATTTGCGGTAGAGGGTAAAGATATTACTGAAGAAGTATTAAAATCTAT CCCTGCTTCTGAAAAAGCACAAGAGAAAAAATAATAGGTTC
Protein Sequence	>AAD23967.1 outer membrane protein 26 [Haemophilus influenzae] MKNIAKVTALALGIALASGYASAEEKIAFINAGYIFQHHPDRQAVADKLDAEFKPVAEKLAASKKEVDDK IAAARKKVEAKVAALEKDAPRLRQADIQKRQEEINKLGAAEDAELQKLMQEQDKKVQEFQAQNEKRQAEE RGKLLDSIQTATNNLARAKGYTYVLDANSVVFAVEGKDITEEVLKSIPASEKAQEKK
Molecule Role	Protective antigen
Molecule Role Annotation	OMP26 was used to immunize rats via intestinal Peyer's patches, followed by an intratracheal boost. Immunization was found to significantly enhance bacterial clearance following pulmonary challenge with both the homologous NTHI strain and a different NTHI strain (Kyd and Cripps, 1998).
Related Vaccines(s)	H. influenzae Omp26 protein vaccine
References

skp