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LASVsSgp2 glycoprotein

Gene Name LASVsSgp2 glycoprotein
Sequence Strain (Species/Organism) Lassa mammarenavirus
VO ID VO_0010869
NCBI Gene ID 956585
NCBI Protein GI 23343511
Locus Tag LASVsSgp2
Genbank Accession AY628203
Protein Accession NP_694870
Taxonomy ID 11620
Segment No segment S
Gene Starting Position 1871
Gene Ending Position 3346
Gene Strand (Orientation) -
Protein Name glycoprotein
Protein pI 7.63
Protein Weight 53529.32
Protein Length 491
DNA Sequence 
>NC_004296.1:1871-3346 Lassa virus segment S, complete sequence
CTCATCTCTTCCATTTCACAGGCACACCAGGCTGTTTGTAGAGTCCACAGGAACAAATGCCCATATGATT
CAATCTGTGAGGTTTGGGACACGACTTGCCTACAATATGCCTATGAGTTGGTATTTTGACTAGGTGAAGG
AAGATGCTAATAAGATAGAAACTTGTACTGAACACAAAGAGGTCAACTAGACCCAATGGTGTCTTCCCCT
GCCTCTCCATATACTCCTTCTGTAACATCTCAGTGATCATATTGTCAGCTTGTTGTTCAATATCATCAGA
AAAGTGGGTCTCGTTCAAGTATGAACCATTTGATACAAGCCAACATTTGGGCAGTGATGTTCTCCCAGTA
GTTGTGTGGTTGAGGTACCAATACTTGCTGTAATTACAGTATGGAATTCCCATGATGTCCCGTAGATGGT
TCTTCATTATAAGTTGGTCATTTATCAAAGCATTTACTGCTTTGTTGATCAACTGAATGCTCATTTGTGC
TTCAGCTTTCAACCTTTGAATGGCTTGTTTGTTGAAGTCAAACAGCCTCAGCATGTCACAAAATTCCTCA
TCATGCTTCTCATTACATTTTGCCACAGCTGTGTTCCCGAAGCATTTTAGTTCAGCCTCAATTAGCATCC
ACCTGGTCAGACAATATCCCCCTGGTGTGTCTTTACCTTCAGAATCTGACAGTGTCCATGTGAATGTGCC
TAGCAATCTTCTACTAATATAAATATCTCTAGTCCTTTGTGAGAGGAGCCCGAGATAACCGATGGGAGAT
GGTCTCGAGAATTGGCAGTGATCTTCCCAGGTTGTATTTTGGATTATCAGATATTGATAACTAGTCATAA
TACAGTCCCAGTTGCCACGGCCTGAGTCAAGAGCAATGTAGCTCCCACCCCAAGCCATCCTCATAAAAGT
CTGTAACACACCATTTGCAACAGTACCACAATGGTTGGCTGCATCCCCAGCATAGCTGTGACTCAGGTTG
TACTGCACACTAATCTTTCCCCCATTAAAATCGCAGCTCATTGCCTCATACTGATTGAAGTTGGGGATGG
ACAAGTGGAAAGTTGAGATTATGCTCATAAGAGCGTGGTCATAGAGGTTCTTTTTGTGGGCATCAGACAG
ATTGCAAAATTTGTGATTAATAATGCTCGTGTTGGTCAAGGTCAGTTCTAGTCCTGTCTCATTGCCCACC
ATTATATAATGATGACTGTTGTTCTTTGTGCAGGAGAGAGGCATGGTCATATTGAGTGTCTCCATGTTTA
GTTCCAGAGTCTGAAGCTCATAAACCCCTTTATAAAGACTGGTTGTGCAAGACCTACCACACAACAGGAG
GAAAGTGACCAAACCAACAAGGCCACACGTTGCAAAATTGTACAGACCTTTCAGCACTGCTAGTACAGAC
AGTGCAATGAGAACAATGTTCATCACCTCTTCTATTACATGAGGCACTTCCTGGAAGAATGTCACTATTT
GTCCCA
Protein Sequence 
>NP_694870.1 glycoprotein [Lassa mammarenavirus]
MGQIVTFFQEVPHVIEEVMNIVLIALSVLAVLKGLYNFATCGLVGLVTFLLLCGRSCTTSLYKGVYELQT
LELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTF
HLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNW
DCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLGLLSQRTRDIYISRRLLGTFTWTLSDSEGKDTPGGYCL
TRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAEAQMSIQLINKAVNALINDQLI
MKNHLRDIMGIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYM
ERQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKSCPKPHRLNHMGICSCGLYKQPGVPVKWK
R
Molecule Role Protective antigen
Molecule Role Annotation HLA-A*0201 mice immunized with either GPC(42-50) from LASVsSgp2 glycoprotein or GPC(60-68) were protected against challenge with a recombinant vaccinia virus that expressed LASV GPC (Botten et al., 2006).
Related Vaccines(s) Lassa fever virus recombinant vector vaccine V-LSG encoding the glycoprotein , Lassa fever virus recombinant vector vaccine V-LSG/N encoding the glycoprotein and the nucleoprotein , ML29 L-AttV, rLCMV(IGR/S-S) (Mopiea/Lassa reassortant) , V-LSGPC , VSV[Delta]G/LVGPC
References