VIOLIN: Vaccine Investigation and Online Information Network

AroA
Gene Name	AroA
Sequence Strain (Species/Organism)	Shigella flexneri 2a str. 2457T
NCBI Gene ID	1077373
NCBI Protein GI	30062442
Locus Tag	S0967
Genbank Accession	NC_004741.1
Protein Accession	NP_836613.1
Taxonomy ID	620
Gene Starting Position	945133
Gene Ending Position	946416
Gene Strand (Orientation)	+
Protein Name	3-phosphoshikimate 1-carboxyvinyltransferase
Protein pI	5.14
Protein Weight	46167.3
Protein Length	427
Protein Note	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
DNA Sequence	>GeneID\|1077373 [Shigella flexneri 2a str. 2457T ] 945133..946416 tacaacccatcgctcgtgtcgatggcactattaatctgcccggttccaagagcgtttctaaccgcgcttt attgcttgcggcattagcacacggcaaaacagtattaaccaatctgctggatagcgacgacgtgcgccat atgctgaatgcattaacagcgttagggttaagctatacgctttcagccgatcgtacgcgttgcgaaatta tcggtaacggcggtccattacacgcagaaggtgccctggagttgttcctcggtaacgccggaacggcaat gcgtccgctggcggcagctctttgtctggatagcaatgatattgtgctgaccggtgagccgcgtatgaaa gagcgcccgattggtcatctggtggatgcgctgcgcctgggcggggcgaagatcacttacctggaacaag aaaattatccgccgttgcgtttacagggcggctttactggcggcaacgttgacgttgatggctccgtttc cagccaattcctcaccgcactgttaatgactgcgcctcttgcgccggaagatacggtgattcgtattaaa ggcgatctggtttctaaaccttatatcgacatcacactcaatctgatgaagacgtttggtgttgaaattg aaaatcagcactatcaacaatttgtcgtaaaaggcgggcagtcttatcagtctccgggtacttatttggt cgaaggcgatgcatcttcggcttcttacttcctggcagcagcagcaatcaaaggcggcactgtaaaagtg accggtattggacgtaacagtatgcagggtgatattcgctttgctgatgtgctggaaaaaatgggcgcga ccatttgctggggcgatgattatatttcctgcacgcgtggtgaactgaacgctattgatatggatatgaa ccatattcctgatgcggcgatgaccattgccacggcggcgttatttgcaaaaggcaccaccacgctgcgc aatatctataactggcgtgttaaagagaccgatcgcctgtttgcgatggcaacagaactgcgtaaagtcg gcgcggaagtggaagaggggcacgattacattcgtatcactcctccggaaaaactgaactttgccgagat cgcgacatacaatgatcaccggatggcgatgtgtttctcgctggtggcgttgtcagatacaccagtgacg attcttgatcccaaatgcacggccaaaacatttccggattatttcgagcagctggcgcggattagccagg cagcctgaatgaacaacgggcaat
Protein Sequence	>gi\|30062442\|ref\|NP_836613.1\| 3-phosphoshikimate 1-carboxyvinyltransferase [Shigella flexneri 2a str. 2457T ] MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGLSYTLSADR TRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLDSNDIVLTGEPRMKERPIGHLVDALRLGGAKI TYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKT FGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVL EKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMAT ELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL ARISQAA
Molecule Role	Virmugen
Molecule Role Annotation	An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri (Noriega et al., 1994).
Related Vaccines(s)	CVD 1204(pGA1-CS2) , S. dysenteriae 1 strain WRSd1 , S. flexneri 2a strain CVD 1203 , S. sonnei strain WRSS1
References

AroA