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VP35

Gene Name VP35
Sequence Strain (Species/Organism) Marburg marburgvirus
VO ID VO_0010929
NCBI Gene ID 920948
NCBI Protein GI 158539110
Locus Tag MARV_gp2
Genbank Accession NC_001608.2
Protein Accession YP_001531154
Taxonomy ID 11269
Gene Starting Position 2853
Gene Ending Position 4409
Gene Strand (Orientation) +
Protein Name mRNA
Protein pI 9.15
Protein Weight 33975.62
Protein Length 329
DNA Sequence 
>NC_001608.3:2853-4409 Marburg marburgvirus isolate Marburg virus/H.sapiens-tc/KEN/1980/Mt. Elgon-Musoke, complete genome
CGAAGAATATTAAAGATTTTCTTTAATATTCAGAAAAGGCTTTTTATTCTATTCTTTCTTTTTACAAACG
TATTGAAATAGTAATTCTCACAATGTGGGACTCATCATACATGCAGCAAGTCAGCGAAGGGTTGATGACT
GGAAAAGTACCCATAGATCAAGTGTTTGGTGCCAATCCCTTAGAGAAGTTATACAAGAGAAGAAAACCAA
AAGGCACAGTTGGACTACAATGTAGCCCTTGTCTAATGTCAAAGGCGACAAGTACTGATGATATTATTTG
GGACCAACTGATCGTGAAGAGAACACTAGCTGATCTACTTATACCGATAAATAGGCAGATATCAGACATT
CAAAGCACTCTAAGCGAAGTAACAACAAGAGTCCATGAAATTGAGCGGCAATTACATGAGATTACCCCAG
TTTTAAAAATGGGAAGGACACTGGAAGCAATTTCCAAGGGGATGTCAGAAATGTTAGCCAAATACGACCA
CCTTGTAATTTCAACTGGAAGAACCACTGCACCAGCTGCTGCCTTTGATGCCTACTTAAATGAGCATGGT
GTCCCTCCCCCTCAACCCGCGATTTTCAAAGATCTTGGGGTTGCCCAACAAGCTTGTAGTAAGGGGACCA
TGGTTAAAAATGCAACAACAGATGCAGCCGACAAGATGTCGAAGGTTCTTGAACTCAGTGAGGAAACGTT
CTCCAAGCCAAACCTTTCAGCTAAGGATTTAGCCCTTTTATTGTTTACCCATCTACCCGGCAACAACACT
CCATTCCATATCCTAGCTCAGGTCCTTTCAAAAATTGCTTACAAGTCAGGAAAATCCGGAGCATTCTTGG
ATGCATTTCACCAGATTCTAAGTGAAGGAGAGAATGCTCAGGCGGCATTAACTCGACTAAGCAGAACATT
TGACGCTTTCCTTGGAGTGGTTCCTCCAGTGATAAGAGTCAAAAACTTCCAAACAGTCCCTCGTCCATGT
CAAAAAAGTCTTCGGGCTGTCCCTCCAAATCCAACAATTGACAAAGGATGGGTCTGTGTTTATTCATCTG
AGCAAGGTGAAACACGGGCCCTTAAAATCTAATTCTCATTGTTCATAGTTGCAAGGGAAGTGATCTTTCC
GAGTTGATACAAAGACACTAAACATTTCAAAAGCATGTATGTGGACAAAACATAATTAGACCATCTTAAT
TGGAGTAGTAATTTATTTCTGTCTTAAATGTGATTTTCACTTTAAAAGCGTTAAATGGTGATAGATTAAT
CCTTGAAGTTACTCTTCTATATATTATAGAGAAACCAATGTTACTAACAAAAGGGGTCTACCTAACGCAT
ATGATTGAGTAATCCGTATATTTTATAAACCAAACAATTAACTTCTTACTTTTTAAGAATCAACTAACAA
CATAGAAAAGACATTTATCCTTATGTAATCCTCGGCTTAGTTGAAATTAACTTTTGTTGGACCTCAAGAC
GCTTATTCATAGTATATTATATGATTTTTTATAAGTTTAAGATATCTTAAATTATACCCACAAAAGATAC
TGTTTTAATTAAGAAAA
Protein Sequence 
>YP_001531154.1 polymerase complex protein [Marburg marburgvirus]
MWDSSYMQQVSEGLMTGKVPIDQVFGANPLEKLYKRRKPKGTVGLQCSPCLMSKATSTDDIIWDQLIVKR
TLADLLIPINRQISDIQSTLSEVTTRVHEIERQLHEITPVLKMGRTLEAISKGMSEMLAKYDHLVISTGR
TTAPAAAFDAYLNEHGVPPPQPAIFKDLGVAQQACSKGTMVKNATTDAADKMSKVLELSEETFSKPNLSA
KDLALLLFTHLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFHQILSEGENAQAALTRLSRTFDAFLGVV
PPVIRVKNFQTVPRPCQKSLRAVPPNPTIDKGWVCVYSSEQGETRALKI
Molecule Role Protective antigen
Molecule Role Annotation Guinea pigs were vaccinated with recombinant VEE replicons (packaged into VEE-like particles), inoculated with MBGV, and evaluated for viremia and survival after challenge with typical MGBV disease. Results indicated that VP35 afforded incomplete protection (Hevey et al., 1998).
Related Vaccines(s) Marburg virus recombinant vector vaccine MBGV GP , Recombinant VEE Replicons expressing MBGV GP
References